Insulin resistance and adiponectin levels in drug-free patients with schizophrenia: A preliminary report
Insulin resistance and adiponectin levels in drug-free patients with schizophrenia: A preliminary report
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DOI：
10.1177/070674370605100608
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发表时间：
2006-05-01
影响因子：
4
通讯作者：
Wolever, Thomas M. S.
中科院分区：
文献类型：
--
作者：
Cohn, Tony A.;Remington, Gary;Wolever, Thomas M. S.
目的：比较未服药的精神分裂症或分裂情感性障碍患者与健康对照者胰岛素敏感性和脂联素水平。方法：我们评估了9名年龄26.6岁（中位26岁，范围17至41岁）的非糖尿病患者和匹配的志愿者，使用频繁采样的静脉葡萄糖耐量试验，最小模型分析和空腹脂联素水平。结果：患者的平均胰岛素敏感性指数比健康志愿者低42% (P = 0.026)，胰岛素分泌代偿不足。精神分裂症患者倾向于降低脂联素水平（P = 0.055）。结论：通过直接测量，本研究为未使用抗精神病药物的精神分裂症患者的胰岛素抵抗和2型糖尿病易感性提供了证据。
Objective: To compare the insulin sensitivity and adiponectin levels of medication-free patients suffering from schizophrenia or schizoaffective disorder with that of matched healthy volunteers.Method: We evaluated 9 nondiabetic patients aged 26.6 years (median 26 years, range 17 to 41 years) and matched volunteers, using the frequently sampled intravenous glucose tolerance test, minimal model analysis, and fasting adiponectin levels.Results: The mean insulin sensitivity index of the patients was 42% lower than that of the healthy volunteers (P = 0.026), with inadequate compensation in insulin secretion. Patients with schizophrenia tended to have reduced adiponectin levels (P = 0.055).Conclusions: By direct measurement, this study provides evidence of insulin resistance and susceptibility to type 2 diabetes in patients with schizophrenia who are free of antipsychotic drugs.