Altered functional connectivity strength in informant-reported subjective cognitive decline: A resting-state functional magnetic resonance imaging study.
Altered functional connectivity strength in informant-reported subjective cognitive decline: A resting-state functional magnetic resonance imaging study.
复制标题
线人报告的主观认知下降中的功能连通性强度改变：静止状态磁共振成像研究。
DOI：
10.1016/j.dadm.2018.08.011
复制
发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Sachdev PS
中科院分区：
文献类型：
--
作者：
Dong C;Liu T;Wen W;Kochan NA;Jiang J;Li Q;Liu H;Niu H;Zhang W;Wang Y;Brodaty H;Sachdev PS
知情人报告的主观认知下降（iSCD）与转化为痴呆的风险较高相关，但iSCD中全脑功能连接强度（FCS）变化的发现有限。样本包括39名iSCD参与者和39名年龄和性别匹配的健康对照。全局绝对（aFCS）和相对功能连接强度分别使用加权度中心性和加权度中心性的z分数进行估计。FreeSurfer用于测量皮质厚度。iSCD患者的aFCS较低，主要在左侧内侧上级额叶、左侧楔前叶、左侧顶叶、右侧楔叶和双侧距状核;而与健康对照组相比，后扣带回皮质/楔前叶的相对功能连接强度较高。未观察到皮质厚度的显著差异。iSCD中存在可检测到的FCS变化，楔前叶可能起代偿作用。因此，FCS可能具有作为神经退行性疾病的最早神经影像学标志物之一的潜在作用。功能连接强度进行了检查，在线人报告的主观认知下降。绝对功能连接强度较低，在默认模式网络中的线人报告的主观认知下降。个体与线人报告的主观认知下降表现出较高的相对功能连接强度的楔前叶。
Informant-reported subjective cognitive decline (iSCD) has been associated with a higher risk of conversion to dementia, but the findings of whole brain functional connectivity strength (FCS) changes in iSCD are limited. The sample comprised 39 participants with iSCD and 39 age- and sex- matched healthy controls. The global absolute (aFCS) and relative functional connectivity strengths were estimated using weighted degree centrality and the z-scores of the weighted degree centrality respectively. FreeSurfer was used for measuring cortical thickness. The aFCS was lower in iSCD primarily in left medial superior frontal, left precuneus, left parietal, right cuneus, and bilateral calcarine; while relative functional connectivity strength was higher in posterior cingulate cortex/precuneus compared with healthy controls. No significant differences in cortical thickness were observed. There are detectable changes of FCS in iSCD, with the precuneus possibly playing a compensatory role. FCS could therefore have a potential role to serve as one of the earliest neuroimaging markers of neurodegenerative disease. Functional connectivity strength was examined in informant-reported subjective cognitive decline. Absolute functional connectivity strength was lower in the default mode network in informant-reported subjective cognitive decline. Individuals with informant-reported subjective cognitive decline showed higher relative functional connectivity strength in precuneus.