Modeling uncertainty in single-copy assays for HIV.
Modeling uncertainty in single-copy assays for HIV.
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HIV 单拷贝检测的不确定性建模。
DOI：
10.1128/jcm.01254-12
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发表时间：
2012
影响因子：
9.4
通讯作者：
Zurakowski,Ryan
中科院分区：
文献类型：
--
作者：
Luo,Rutao;Piovoso,MichaelJ;Zurakowski,Ryan
我们提出了一个简单的计算模型的测量准确性的单拷贝灵敏度测定（SCA）的HIV RNA，是从第一原则。该模型表明，SCA是显着的右偏。测得的病毒浓度为1和10个病毒粒子/ml，具有重叠的95%置信区间，在统计学上无法区分。
We present a simple computational model of measurement accuracy for single-copy sensitivity assays (SCA) of HIV RNA that was developed from first principles. The model shows that the SCA is significantly right-skewed. Measured virus concentrations of 1 and 10 virions/ml had overlapping 95% confidence intervals and were statistically indistinguishable.