Skeletal muscle ischemia-reperfusion causes transitory increase in microvascular protein permeability.
Skeletal muscle ischemia-reperfusion causes transitory increase in microvascular protein permeability.
复制标题
骨骼肌缺血再灌注导致微血管蛋白质通透性短暂增加。
DOI：
10.1152/ajpheart.1997.273.1.h303
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Bell,DR
中科院分区：
文献类型：
--
作者：
Kupinski,AM;Bock,DE;Bell,DR
本研究的目的是确定除了影响初始变化的大小外，骨骼肌缺血时间的长短是否会影响再灌注时微血管通透性的恢复。在麻醉的家兔中，在缺血1、2、3、4小时后的第1、2、3、4小时，测量腓肠肌和比目鱼肌中标记白蛋白的经血管清除率。在再灌注的第一个小时内，白蛋白清除率、组织水分和髓过氧化物酶活性的增加程度取决于缺血的时间长短。再灌注后第4小时白蛋白清除率恢复到控制值与缺血时间无关。在再灌注的4小时内，组织水、血管外天然白蛋白团块和髓过氧化物酶活性保持升高。缺血4 h后，再灌注1 h时白蛋白的溶剂阻力反射系数明显低于对照组。再灌注第4小时的数值与对照组无显著差异。这些结果表明，在再灌注的最初几个小时内，引起渗透性变化的炎症介质被从微血管中冲走。
The aim of this study was to determine whether the length of ischemia in skeletal muscle influences the return of normal microvascular permeability during reperfusion in addition to influencing the size of the initial changes. In anesthetized rabbits, the transvascular clearance of labeled albumin was measured in the gastrocnemius and soleus muscles during the first, second, third, or fourth hour of reperfusion after 1, 2, 3, or 4 h of ischemia. The size of the increases in albumin clearance, tissue water, and myeloperoxidase activity during the first hour of reperfusion was dependent on the length of ischemia. The return of the albumin clearance to control values during the fourth hour of reperfusion was independent of the length of ischemia. Tissue water, extravascular mass of native albumin, and myeloperoxidase activity remained elevated during the 4 h of reperfusion. After 4 h of ischemia, the solvent-drag reflection coefficient for albumin was significantly less than control during the first hour of reperfusion. The value during the fourth hour of reperfusion was not significantly different from control. These results suggest that the inflammatory mediators producing a change in permeability are washed out of the microvasculature during the first few hours of reperfusion.