The Liver in Sickle Cell Disease
The Liver in Sickle Cell Disease
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DOI：
10.1016/j.cld.2018.12.002
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发表时间：
2019-05-01
影响因子：
5.1
通讯作者：
Suddle, Abid R.
中科院分区：
文献类型：
--
作者：
Theocharidou, Eleni;Suddle, Abid R.
镰状细胞病的患者可能会因肝内红细胞镰刀样改变而发展为肝病，因多次输血而继发的病毒性肝炎和铁超载，以及由于慢性溶血而导致的胆石症。临床肝病的范围很广，往往是多因素的。一些患者发展为肝硬变，可能发展为终末期肝功能衰竭。目前关于药物治疗的证据有限。换血可能会改善急性肝综合征的预后。肝移植可能是治疗慢性肝病的一种选择。预防性胆囊切除术在预防胆石症并发症中的作用存在争议。
Patients with sickle cell disease can develop liver disease as a result of intrahepatic sickling of erythrocytes, viral hepatitis and iron overload secondary to multiple blood transfusions, and gallstone disease as a result of chronic hemolysis. The spectrum of clinical liver disease is wide and often multifactorial. Some patients develop cirrhosis that may progress to end-stage liver failure. Limited evidence exists for medical treatments. Exchange blood transfusions may improve outcomes in the acute liver syndromes. Liver transplantation may be an option for chronic liver disease. The role for prophylactic cholecystectomy in preventing complications of gallstone disease is controversial.