Reduced incidence of necrotizing enterocolitis associated with enteral administration of Lactobacillus acidophilus and Bifidobacterium infantis to neonates in an intensive care unit.
Reduced incidence of necrotizing enterocolitis associated with enteral administration of Lactobacillus acidophilus and Bifidobacterium infantis to neonates in an intensive care unit.
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DOI：
10.1016/s1201-9712(99)90024-3
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发表时间：
1999-01-01
期刊：
影响因子：
--
通讯作者：
Hoyos, A B
中科院分区：
文献类型：
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作者：
Hoyos, A B
坏死性小肠结肠炎（NEC）与多种细菌及其细胞毒素有关。需要重症监护住院的新生儿肠道细菌定植的内容和性质已被证明是异常的。在哥伦比亚波哥大的西蒙玻利瓦尔医院的25张病床的新生儿重症监护病房，NEC病例是发病和死亡的常见原因。这篇文章检查了这样一个假设，即在重症监护室中对所有新生儿口服预防性嗜酸乳杆菌和双歧杆菌，将降低NEC的发病率。嗜酸乳杆菌和2.5亿B.对1年内入住该单位的所有1237名新生儿（包括住院患者和转院患者）进行了连续监测，直到他们出院。在这项研究中，1282例住院病人在过去的一年作为对照。嗜酸乳杆菌和B.婴儿。对研究组的出生地、临床和人口统计学变量进行了比较，这些变量没有统计学显著差异。在历史对照组中，有85例NEC病例，而接受益生菌预防的组中有34例（P < 0.0002）。在历史对照组中，有35例NEC相关的死亡，而在接受益生菌预防的组中有14例死亡（P < 0.005）。结论：本研究的阳性结果支持需要进一步研究细菌定植及其在NEC中的作用。
OBJECTIVES: Necrotizing enterocolitis (NEC) has been associated with a wide variety of bacteria and their cytotoxins. The content and the nature of gut bacterial colonization in newborns that require intensive care hospitalization has been demonstrated to be abnormal. In the 25-bed neonatal intensive care unit in Hospital Simon Bolivar, in Bogota, Colombia, cases of NEC are common causes of morbidity and mortality. This article examines the hypothesis that oral administration of prophylactic Lactobacillus acidophilus and Bifidobacterium infantis to all neonates in an intensive care unit, would decrease the incidence of NEC.METHODS: Daily doses of 250 million live L. acidophilus and 250 million B. infantis were given to all 1237 newborns (both inpatients and transfer patients) admitted to the unit during 1 year, until they were discharged from the hospital. In this study, 1282 patients hospitalized during the previous year were used as controls.RESULTS: There were no complications attributed to the daily administration of L. acidophilus and B. infantis. The study groups were compared for place of origin, clinical, and demographic variables, and there was no statistically significant difference in those variables. In the historic control group, there were 85 NEC cases compared to 34 cases in the group that received probiotic prophylaxis (P < 0.0002). In the historic control group, there were 35 NEC-associated fatalities compared to 14 fatalities in the group that received probiotic prophylaxis (P < 0.005).CONCLUSIONS: The positive results in this study support the need for further investigation of bacterial colonization and its role in NEC.