Anemia and Red Blood Cell Transfusion Advances in Critical Care
Anemia and Red Blood Cell Transfusion Advances in Critical Care
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DOI：
10.1016/j.ccc.2016.12.011
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发表时间：
2017-04-01
影响因子：
4.3
通讯作者：
Napolitano, Lena M.
中科院分区：
文献类型：
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作者：
Napolitano, Lena M.
贫血在重症监护病房(ICU)很常见，导致频繁输注红细胞(RBC)。在理解ICU中贫血的病理生理学方面取得了重大进展，这是一种炎症性贫血。这种贫血与高浓度的海普西丁导致铁限制的红细胞生成和红细胞生成素浓度降低有关。一种新的激素(红铁酮)已经被发现，它介导了海普西丁的抑制，从而增加了铁的吸收和从铁储存中动员。输注红细胞是ICU患者治疗贫血最常用的方法。应执行所有减少ICU贫血的战略。
Anemia is common in the intensive care unit (ICU), resulting in frequent administration of red blood cell (RBC) transfusions. Significant advances have been made in understanding the pathophysiology of anemia in the ICU, which is anemia of inflammation. This anemia is related to high hepcidin concentrations resulting in iron-restricted erythropoiesis, and decreased erythropoietin concentrations. A new hormone (erythroferrone) has been identified, which mediates hepcidin suppression to allow increased iron absorption and mobilization from iron stores. RBC transfusions are most commonly administered to ICU patients for treatment of anemia. All strategies to reduce anemia in the ICU should be implemented.