INTESTINAL-ABSORPTION, SERUM CLEARANCE, AND INTERACTIONS BETWEEN LUTEIN AND BETA-CAROTENE WHEN ADMINISTERED TO HUMAN ADULTS IN SEPARATE OR COMBINED ORAL DOSES
INTESTINAL-ABSORPTION, SERUM CLEARANCE, AND INTERACTIONS BETWEEN LUTEIN AND BETA-CAROTENE WHEN ADMINISTERED TO HUMAN ADULTS IN SEPARATE OR COMBINED ORAL DOSES
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DOI：
10.1093/ajcn/62.3.604
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发表时间：
1995-09-01
影响因子：
7.1
通讯作者：
OLSON, JA
中科院分区：
文献类型：
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作者：
KOSTIC, D;WHITE, WS;OLSON, JA
给8名成年受试者一次等摩尔剂量的叶黄素和/或β-胡萝卜素油性真溶液，在随后的840h内采集13份血样，叶黄素的平均血药浓度在16h出现单峰，β-胡萝卜素的平均血药浓度在6h达到峰值，然后在32h再次达到峰值。随后，叶黄素和β-胡萝卜素从血清中的清除速度大致相同。叶黄素和β-胡萝卜素在前440h的平均曲线下面积(AUC)分别为59.6+/-9.0和26.3+/-6.4mmol.H/L，分别(P<；0.005)。AUC值与给予类胡萝卜素的初始血清浓度或给药顺序无关。当以相同剂量组合时，β-胡萝卜素显著降低血清叶黄素的AUC值至对照组的54-61%(P<；0.025)，而叶黄素降低了5个受试者的β-胡萝卜素的AUC值，但增加了3个受试者的AUC值。叶黄素对β-胡萝卜素的AUC的影响与单独对β-胡萝卜素的AUC呈负相关。因此，在肠道吸收、新陈代谢和血清清除过程中，类胡萝卜素明显相互作用，尽管个体的反应可能明显不同。
Single equimolar doses (0.5 mu mol/kg body wt) of lutein and/or beta-carotene in true solution in oil were given to eight adult subjects and 13 blood samples were taken during the subsequent 840 h. Whereas the mean serum concentration of lutein showed a single maximum at 16 h, that of beta-carotene peaked at 6 h and then again at 32 h. Subsequently, lutein and beta-carotene were cleared at approximately the same rate from the serum. The mean (+/- SEM) areas under the curve (AUCs) for lutein and beta-carotene during the first 440 h differed significantly: 59.6 +/- 9.0 and 26.3 +/- 6.4 mu mol . h/L, respectively (P < 0.005). AUC values did not correlate with initial serum concentrations of the given carotenoid or with the order of dosing. When combined in the same dose, beta-carotene significantly reduced the serum AUC values for lutein to 54 - 61% of control values (P < 0.025), whereas lutein reduced the AUC value for beta-carotene in five subjects but enhanced it in three subjects. Effects of lutein on the AUC for beta-carotene were inversely related to the AUC for beta-carotene alone. Thus, carotenoids clearly interact with each other during intestinal absorption, metabolism, and serum clearance, although individual responses can differ markedly.