Mitigating or Exacerbating Effects of Maternal-Fetal Programming of Female Mice Through the Food Choice Environment
Mitigating or Exacerbating Effects of Maternal-Fetal Programming of Female Mice Through the Food Choice Environment
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DOI：
10.1210/en.2014-1523
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发表时间：
2015-01-01
期刊：
影响因子：
4.8
通讯作者：
Good, Deborah J.
中科院分区：
文献类型：
--
作者：
Brenseke, Bonnie;Bahamonde, Javiera;Good, Deborah J.
人类在复杂的环境中生活、进食并变得超重/肥胖，其中有许多可用的食物选择。产前暴露于不良的食物选择易使后代增加负面健康风险，包括肥胖。许多动物实验分析了在没有食物选择的环境中的代际体重参数，这可能无法直接转化为人类的食物环境。在这项研究中，从定义的高脂肪饮食（HFD）或低脂饮食（LFD）的母亲的后代被任意分配到一个专门的LFD或HFD或饮食中，他们有LFD和HFD之间的选择（选择饮食）。与LFD后代相比，后代在选择饮食时表现出体重、体脂、血清瘦素和血糖水平增加的负面结果。相反，改善的能量消耗被发现的后代相比，从HFD母鼠LFD的选择饮食。此外，确定了母体饮食对后代代谢参数的特定影响，特别是在HFD母鼠的后代中，包括LFD后代中瘦素减少的积极结果，HFD后代中皮质酮和胆固醇水平降低，选择后代中运动水平增加，以及HFD母鼠的LFD后代中卡路里摄入增加的消极结果。这个定义的模型现在可以作为未来研究的基础，以表征代际和代内肥胖的周期，以及更现实的饮食环境，特别是那些包括选择，是否可以减轻表型。
Humans live, eat, and become overweight/obese in complex surroundings where there are many available food choices. Prenatal exposure to poor food choices predisposes offspring to increased negative health risks, including obesity. Many animal experiments have analyzed intergenerational body weight parameters in an environment without food choices, which may not be directly translatable to the human food environment. In this study, offspring from mothers with a defined high-fat diet (HFD) or low-fat diet (LFD) were arbitrarily assigned to either an exclusively LFD or HFD or to a diet where they have a choice between LFD and HFD (choice diet). Offspring displayed negative outcomes of increased body weight, body fat, serum leptin, and blood glucose levels when given the choice diet compared with offspring on the LFD. Conversely, improved energy expenditure was found for offspring given the choice diet compared with offspring from HFD dams given LFD. In addition, maternal diet-specific influences on offspring metabolic parameters were identified, especially in offspring from HFD dams, including positive outcomes of reduced leptin in LFD offspring, reduced corticosterone and cholesterol levels in HFD offspring, and increased exercise levels in choice offspring, as well as the negative outcome of increased calorie intake in LFD offspring from HFD dams. This defined model can now be used as the basis for future studies to characterize the cycle of inter- and intragenerational obesity and whether more realistic diet environments, especially those including choice, can mitigate phenotype.