A high-throughput, multi-channel photon-counting detector with picosecond timing
A high-throughput, multi-channel photon-counting detector with picosecond timing
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DOI：
10.1016/j.nima.2009.01.053
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发表时间：
2009-06-01
影响因子：
1.4
通讯作者：
Milnes, J.
中科院分区：
文献类型：
--
作者：
Lapington, J. S.;Fraser, G. W.;Milnes, J.
具有高时间分辨率的高通量光子计数是一个利基应用领域，在这个领域，真空管的性能仍然可以超过固态设备。利用时间分辨光谱学在生命科学中的应用，特别是在不断增长的蛋白质组学领域，将从事件计时和探测器吞吐量的性能增强中受益匪浅。HiContent项目是莱斯特大学空间研究中心、欧洲核子研究中心微电子小组、Photek有限公司以及格雷癌症研究所和曼彻斯特大学的最终用户之间的合作项目。其目标是开发一种专门为光学蛋白质组学设计的探测器系统。能够在高吞吐量下进行高含量(多参数)分析。正在开发HiContent探测器系统，以开拓这一利基市场。它将多通道、高时间分辨率的光子计数与集成电子技术结合在一个小型化的探测器系统中。使能技术的结合；具有非常高时间分辨率的小孔微通道板器件，以及为欧洲核子研究中心大型强子对撞机开发的高速多通道ASIC电子学，为高通量探测器系统提供了必要的构建块，最高可达1024个并行计数通道和20ps的时间分辨率。我们描述了探测器和电子设计，讨论了HiContent项目的现状，并展示了通道原型系统的结果。在没有工作探测器的情况下，我们使用脉冲发生器来模拟探测器事件来测量电子性能。将使用快速数字示波器捕获的尼诺高速前端ASIC的事件时序结果与使用多通道HPTDC时序ASIC的建议电子配置获得的数据进行比较。(C)2009爱思唯尔B.V.保留所有权利。
High-throughput photon counting with high time resolution is a niche application area where vacuum tubes can still outperform solid-state devices. Applications in the life sciences utilizing time-resolved spectroscopies, particularly in the growing field of proteomics, will benefit greatly from performance enhancements in event timing and detector throughput.The HiContent project is a collaboration between the University of Leicester Space Research Centre, the Microelectronics Group at CERN, Photek Ltd., and end-users at the Gray Cancer Institute and the University of Manchester. The goal is to develop a detector system specifically designed for optical proteomics. capable of high content (multi-parametric) analysis at high throughput. The HiContent detector system is being developed to exploit this niche market. It combines multi-channel, high time resolution photon counting in a single miniaturized detector system with integrated electronics. The combination of enabling technologies; small pore microchannel plate devices with very high time resolution, and high-speed multi-channel ASIC electronics developed for the LHC at CERN, provides the necessary building blocks for a high-throughput detector system with up to 1024 parallel counting channels and 20 ps time resolution.We describe the detector and electronic design, discuss the current status of the HiContent project and present the results from a 64-channel prototype system. In the absence of an operational detector, we present measurements of the electronics performance using a pulse generator to simulate detector events. Event timing results from the NINO high-speed front-end ASIC captured using a fast digital oscilloscope are compared with data taken with the proposed electronic configuration which uses the multi-channel HPTDC timing ASIC. (C) 2009 Elsevier B.V. All rights reserved.