Interactive effects of soy protein and estradiol on coronary artery reactivity in atherosclerotic, ovariectomized monkeys.
Interactive effects of soy protein and estradiol on coronary artery reactivity in atherosclerotic, ovariectomized monkeys.
复制标题
大豆蛋白和雌二醇对动脉粥样硬化、卵巢切除猴冠状动脉反应性的相互作用。
DOI：
10.1097/00042192-200109000-00003
复制
发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Herrington,DM
中科院分区：
文献类型：
--
作者：
Williams,JK;Anthony,MS;Herrington,DM
ObjectiveResults of recent clinical trials indicate that mammalian estrogens may be less effective in reducing coronary heart disease risk than once thought. This study was designed to determine whether mammalian estrogen's coronary artery dilator benefits could be enhanced by adding soy with phytoestrogens.DesignForty-five atherosclerotic, ovariectomized monkeys were fed one of four diets:(1) atherogenic diet with casein/lactalbumin as source of protein (Casein, n= 12);(2) casein diet with micronized estradiol equivalent to a woman's dose of 1 mg/day (Casein+ E 2, n= 12);(3) atherogenic diet with soy protein with phytoestrogens (129 mg woman/day equivalent)(Soy, n= 11); and (4) the soy diet plus estradiol (Soy+ E 2, n= 10).MethodsQuantitative angiography and intravascular Doppler were done after 6 months of experimental diet to measure changes in diameter and coronary flow reserve in the circumflex coronary artery in response to intracoronary acetylcholine and nitroglycerin.ResultsArteries from the E 2 and Soy+ E 2 groups dilated in response to acetylcholine 5±3% and 12±5%, respectively (p< 0.05 vs. Casein). There was an interactive effect of soy and E 2 on dilator response to acetylcholine (p< 0.05). Flow reserve was greatest in animals fed casein+ E 2 and soy+ E 2 (2.3±0.3 and 2.6±0.5, respectively; p< 0.05 vs. Casein). Soy protein alone had no effect on coronary artery reactivity (p> 0.05).ConclusionSoy protein itself does not affect coronary artery dilator responses but interacts with estradiol to promote dilator responses to acetylcholine.
