A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus
A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus
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DOI：
10.1126/science.1128393
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发表时间：
2006-06-09
期刊：
影响因子：
56.9
通讯作者：
Mekalanos, John J.
中科院分区：
文献类型：
--
作者：
Mougous, Joseph D.;Cuff, Marianne E.;Mekalanos, John J.
Bacterial pathogens frequently use protein secretion to mediate interactions with their hosts. Here we found that a virulence locus (HSI-I) of Pseudomonas aeruginosa encodes a protein secretion apparatus. The apparatus assembled in discrete subcellular locations and exported Hcp1, a hexameric protein that forms rings with a 40 angstrom internal diameter. Regulatory patterns of HSI-I suggested that the apparatus functions during chronic infections. We detected Hcp1 in pulmonary secretions of cystic fibrosis (CF) patients and Hcp1-specific antibodies in their sera. Thus, HSI-I likely contributes to the pathogenesis of P. aeruginosa in CF patients. HSI-I-related loci are widely distributed among bacterial pathogens and may play a general role in mediating host interactions.
