Engineering control into medicine
Engineering control into medicine
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DOI：
10.1016/j.jcrc.2015.01.019
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发表时间：
2015-06-01
影响因子：
3.7
通讯作者：
Csete, Marie
中科院分区：
文献类型：
--
作者：
Stone, David J.;Celi, Leo Anthony;Csete, Marie
人体是一个严格控制的工程奇迹。然而，医学培训通常不包括生理学、病理生理学和治疗学中的“控制”（在工程学意义上）。更好地理解进化的控制如何维持正常的稳态对于理解受控系统的故障模式，即疾病至关重要。我们认为，教学和研究必须结合生理学中的控制系统的理解，并利用工程学所使用的定量工具来理解复杂的系统。控制系统在生理学中无处不在，尽管经常被忽视。在这里，我们提供了控制在生理学（心率变异性，免疫力），病理生理学（败血症炎症）和治疗设备（糖尿病和人工胰腺）中的作用的选择的例子。我们还提出了一个高层次的背景下，鲁棒控制系统的概念和使用控制框架的临床见解的例子。(C)2014 Elsevier Inc. All rights reserved.
The human body is a tightly controlled engineering miracle. However, medical training generally does not cover "control" (in the engineering sense) in physiology, pathophysiology, and therapeutics. A better understanding of how evolved controls maintain normal homeostasis is critical for understanding the failure mode of controlled systems, that is, disease. We believe that teaching and research must incorporate an understanding of the control systems in physiology and take advantage of the quantitative tools used by engineering to understand complex systems.Control systems are ubiquitous in physiology, although often unrecognized. Here we provide selected examples of the role of control in physiology (heart rate variability, immunity), pathophysiology (inflammation in sepsis), and therapeutic devices (diabetes and the artificial pancreas). We also present a high-level background to the concept of robustly controlled systems and examples of clinical insights using the controls framework. (C) 2014 Elsevier Inc. All rights reserved.