Influence of formalin fixation on the implant stability quotient and mechanical characteristics of bone
Influence of formalin fixation on the implant stability quotient and mechanical characteristics of bone
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DOI：
10.1016/j.bjoms.2012.08.009
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发表时间：
2013-09-01
影响因子：
1.8
通讯作者：
Akagawa, Yasumasa
中科院分区：
文献类型：
--
作者：
Morita, Koji;Doi, Kazuya;Akagawa, Yasumasa
种植体稳定性商数 (ISQ) 已在临床研究和动物实验中得到广泛评估。然而，在动物模型中准确测量通常很困难。在这种情况下，需要在福尔马林固定后测量骨中的 ISQ。然而，目前尚不清楚这种固定如何影响测量。本研究的目的是探讨福尔马林固定对 ISQ 和骨力学特性的影响。从兔子身上采集了十四根胫骨；左侧样品（长度60 mm，对照组）浸泡在盐水中，右侧样品（长度60 mm，固定组）在10%中性缓冲福尔马林中4℃固定4小时。以 5 毫米/分钟的速度进行三点弯曲测试，以测量最大负载和总吸收能量。将 12 个钛种植体（Branemark System (R) Mk-III TiUnite，Nobel Biocare，瑞典）植入 2 只狗下颌骨的无牙磨牙部位，3 个月后由 Osstell (R)（对照组）测量 ISQ。然后将参与骨块的种植体固定4小时（固定组）并测量ISQ。对照组和固定组之间的最大负载值没有显着差异。对照组的总吸收能量显着高于固定组。 ISQ 在各组之间没有显着差异。这些结果表明，福尔马林固定骨可能会影响骨的一些机械特性，但不会影响其 ISQ。 (C) 2012 年英国口腔颌面外科医师协会。由爱思唯尔有限公司出版。保留所有权利。
The implant stability quotient (ISQ) has been widely evaluated in clinical studies and animal experiments. However, accurate measurement is often difficult in animal models. In such cases, measurement of ISQ in bone is needed after formalin fixation. However, it is not yet clear how such fixation influences the measurement. The purpose of this study was to investigate the influence of formalin fixation on ISQ and the mechanical characteristics of bone. Fourteen tibias were harvested from rabbits; the samples from the left (length 60 mm, control group) were soaked in saline and the samples from the right (length 60 mm, fixation group) were fixed in 10% neutral-buffered formalin at 4 degrees C for 4 h. Three-point bending tests were done at 5 mm/min to measure the maximum load and total absorbed energy. Twelve titanium implants (Branemark System (R) Mk-III TiUnite, Nobel Biocare, Sweden) were placed into the edentulous molar site of the mandibles of 2 dogs and the ISQ was measured by Osstell (R) (control group) 3 months later. The implants involved in the bone block were then fixed for 4h (fixation group) and the ISQ measured. The maximum load values did not differ significantly between the control and fixation groups. Total absorbed energy was significantly higher in the control group than in the fixation group. ISQ did not differ significantly between the groups. These results suggest that formalin fixation of bone might affect some of the mechanical characteristics of bone, but not its ISQ. (C) 2012 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.