Health-Related Quality of Life Following Allogeneic Hematopoietic Stem Cell Transplantation
Health-Related Quality of Life Following Allogeneic Hematopoietic Stem Cell Transplantation
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DOI：
10.1182/asheducation-2010.1.248
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发表时间：
2010-12-01
影响因子：
3
通讯作者：
Bevans, Margaret
中科院分区：
文献类型：
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作者：
Bevans, Margaret
众所周知，异基因造血干细胞移植（HSCT）将对移植受者及其家人的生活产生巨大影响。一旦确定了合适的供体，这种治疗的治愈潜力通常会促使人们决定继续进行，因为他们知道会有强烈的生理毒性和对健康相关生活质量（HRQL）的不良影响。25年前，HRQL被确定为评价新抗癌药物治疗的疗效参数。总体而言，证据表明，同种异体HSCT对接受者的总体HRQL有显著影响，这是所有维度（包括显著的症状特征）下降的结果。对整体HRQL和多个维度的影响程度在移植轨迹中各不相同。特定的HRQL维度，如身体功能和症状，很容易纳入临床医生的评估，而其他维度（如，心理社会）是不太常见的集成。HRQL结果的翻译，以改善临床实践还没有很好地建立。临床医生通常不确定何时评估HRQL的范围以及如何以临床有意义的方式解释信息。本文综述了异基因造血干细胞移植对生活质量的影响，并讨论了其在临床实践中的应用。
It is common knowledge that an allogeneic hematopoietic stem cell transplantation (HSCT) will have an enormous impact on the lives of transplant recipients and their families. Once an appropriate donor is identified, the curative potential of this treatment often drives the decision to proceed knowing that there will be intense physiologic toxicities and adverse effects on health-related quality of life (HRQL). Twenty-five years ago, HRQL was identified as an efficacy parameter in the evaluation of new anticancer drug therapy. Overall, the evidence suggests that an allogeneic HSCT has a significant impact on the overall HRQL of recipients, which is a result of decrements across all dimensions, including a significant symptom profile. The degree of impact on overall HRQL and the multiple dimensions varies across the transplant trajectory. Specific HRQL dimensions, such as physical function and symptoms, are easily incorporated into a clinician's assessment whereas other dimensions (eg, psychosocial) are less commonly integrated. The translation of HRQL results to improve clinical practice is not well established. Clinicians are often uncertain when to assess the scope of HRQL and how to interpret the information in a clinically meaningful way. The purpose of this review is to highlight the quality-of-life effects of allogeneic HSCT and discuss application into clinical practice.