Stimulation in Hippocampal Region CA1 in Behaving Rats Yields Long-Term Potentiation when Delivered to the Peak of Theta and Long-Term Depression when Delivered to the Trough
Stimulation in Hippocampal Region CA1 in Behaving Rats Yields Long-Term Potentiation when Delivered to the Peak of Theta and Long-Term Depression when Delivered to the Trough
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DOI：
10.1523/jneurosci.23-37-11725.2003
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发表时间：
2003-12
期刊：
影响因子：
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通讯作者：
James M. Hyman;Bradley P. Wyble;Vikas Goyal;Christina A. Rossi;M.E. Hasselmo
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文献类型：
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作者：
James M. Hyman;Bradley P. Wyble;Vikas Goyal;Christina A. Rossi;M.E. Hasselmo
实验证据表明，海马theta节律在学习中起着关键作用。以前的研究表明，在麻醉大鼠CA1区局部theta节律的峰处刺激长时程增强(LTP)，在麻醉动物和行为动物中都优先刺激theta峰的穿支通路。我们开始确定在脑电中theta节律的高峰或低谷期间，在清醒的行为动物中，在CA1区辐射层进行强直爆发刺激的效果。爆发波到达峰值后，潜在斜率增加了17.9±0.94%。对局部theta波谷给予相同的脉冲刺激时，电位斜率下降12.9±1.03%。这是首次报道在CA1区表现的动物在局部theta节律的峰值优先诱导LTP，并在局部theta波谷对强直刺激的反应发现LTP。结果在最近的理论框架内进行了讨论，该理论提出，theta节奏设置了编码和提取的交替阶段的动力学(Hasselmo等人，20021)。
Experimental evidence suggests that the hippocampal theta rhythm plays a critical role in learning. Previous studies have shown long-term potentiation (LTP) to be preferentially induced with stimulation on the peak of local theta rhythm in region CA1 in anesthetized rats and with stimulation of the perforant path at the peak of theta in both anesthetized and behaving animals. We set out to determine the effects of tetanic burst stimulation in stratum radiatum of region CA1 in awake behaving animals, delivered during either the peak or the trough of the theta rhythm in the EEG. Bursts delivered to the peak resulted in an increase of 17.9 ± 0.94% in potential slope. When identical stimulation bursts were delivered to the trough of local theta waves, the potential slope decreased 12.9 ± 1.03%. This is the first report of LTP being preferentially induced at the peak of local theta rhythm in behaving animals in region CA1 and that LTD was found in response to tetanic stimulation at the trough of the local theta wave. The results are discussed within the framework of a recent theory that proposes that the theta rhythm sets the dynamics for alternating phases of encoding and retrieval (Hasselmo et al., 20021).