Mitogenic activation of human T lymphocytes induces a high affinity morphine binding site.
Mitogenic activation of human T lymphocytes induces a high affinity morphine binding site.
复制标题
人 T 淋巴细胞的有丝分裂激活诱导高亲和力吗啡结合位点。
DOI：
10.1007/978-1-4615-1951-5_6
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发表时间：
1995
影响因子：
--
通讯作者：
Oleson,D
中科院分区：
文献类型：
--
作者：
Madden,JJ;Ketelsen,D;Whaley,WL;Donahoe,RM;Oleson,D
Activation of human T lymphocytes by mitogens or cytokines is a key event in the control of surface receptors central to the metabolism of these cells. Receptors for a wide range of compounds such as IL-2 (1) and serotonin (2) can be induced on human T lymphocytes by phytohemagglutin (PHA) and IL-2, alone or in combination. Similarly, PHA plus IL-1 induces an opiate receptor on murine thymocytes (3). We report below that treatment of human T lymphocytes by PHA followed by incubation with IL-2 leads to the appearance of a saturable morphine binding site. Morphine binding to this site is displaceable by both naloxone and B-endorphin, but not by such classic mu ligands as DAGO or morphiceptin.
