Three cases of “spice” exposure
Three cases of “spice” exposure
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三起“辣妹”曝光案例
DOI：
10.3109/15563650.2011.584316
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发表时间：
2011
影响因子：
3.3
通讯作者：
Carl G. Skinner
中科院分区：
文献类型：
--
作者：
Joshua Simmons;Laura Cookman;C. Kang;Carl G. Skinner
介绍。我们描述了三个通过检测尿液中代谢物 JWH-018 和/或 JWH-073 确认接触“香料”的病例。所有病例的尿液药物筛查均为阴性。病例 1. 一名 25 岁男性，因吸食“香料”产品后可能出现癫痫、心动过速、酸中毒和反应迟钝等症状，被送往当地急诊科 (ED)。通过服用苯二氮卓类药物、输液和观察，他的症状得到了缓解。他的尿液检测结果 JWH-018 呈阳性，JWH-073 代谢物呈阴性。案例2：一名21岁男性在吸食“香料”后被发现失去知觉。他患有高血压，情绪激动，格拉斯哥昏迷评分为 7 分；病人接受了插管。皮肤温暖而干燥。通过静脉输液，他的症状得到缓解，24 小时后出院回家。他的尿液 JWH-018 和 JWH-073 代谢物检测呈阳性。案例 3. 一名 19 岁男性在吸食“香料”产品并出现偏执和妄想 1 小时后被送往急诊室。他的尿液 JWH-018 和 JWH-073 代谢物检测呈阳性。观察数小时后，他已无症状出院。讨论。香料产品是新产品，但因其心理作用和情绪改变而被滥用。这些病例表现出与抗胆碱能药物或拟交感神经药物一致的变化，这些变化在一般支持治疗后得到缓解。
Introduction. We describe three cases with confirmed exposure to “spice” by detection of the metabolites JWH-018 and/or JWH-073 in urine. All cases had a negative urine drug screen. Case 1. A 25-year-old male with possible seizure, tachycardia, acidosis, and unresponsiveness, presented to a local emergency department (ED) after smoking a “spice” product. His symptoms resolved with benzodiazepines, fluid, and observation. His urine tested positive for JWH-018 and negative for JWH-073 metabolites. Case 2. A 21-year-old male was found unresponsive after smoking “spice.” He had hypertension, was agitated, and had a Glasgow Coma Score of 7; the patient was intubated. The skin was warm and dry. His symptoms resolved with IV fluids and he was discharged home after 24 h. His urine tested positive for metabolites of JWH-018 and JWH-073. Case 3. A 19-year-old male was brought to the ED 1 h after smoking a “spice” product and having paranoia and delusions. His urine tested positive for JWH-018 and JWH-073 metabolites. He was discharged asymptomatic after observation for a few hours. Discussion. Spice products are new and abused for their psychogenic effects and mood alteration. These cases exhibited changes consistent with either an anticholinergic or sympathomimetic agent that resolved following general supportive care.