Sendai virus-specific T-cell clones: induction of cytolytic T cells by an anti-idiotypic antibody directed against a helper T-cell clone.
Sendai virus-specific T-cell clones: induction of cytolytic T cells by an anti-idiotypic antibody directed against a helper T-cell clone.
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仙台病毒特异性 T 细胞克隆：通过针对辅助 T 细胞克隆的抗独特型抗体诱导溶细胞 T 细胞。
DOI：
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发表时间：
1984
影响因子：
11.1
通讯作者：
R. Finberg
中科院分区：
文献类型：
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作者：
H. Ertl;R. Finberg
我们使用针对仙台病毒特异性辅助性t细胞克隆的单克隆抗独特型抗体在体内诱导抗病毒免疫应答。用抗独特型抗体引物的脾细胞介导抗原特异性的细胞溶解反应。用抗独特型抗体对小鼠进行预免疫，可防止随后的仙台病毒致命感染。
We used a monoclonal anti-idiotypic antibody that is directed against a Sendai virus-specific helper T-cell clone to induce an anti-viral immune response in vivo. Splenocytes primed with the anti-idiotypic antibody mediated an antigen-specific cytolytic response. Preimmunization of mice with the anti-idiotypic antibody resulted in protection against a subsequent lethal infection with Sendai virus.