Induction of Aberrant Crypt Foci in the Large Intestine of F344 Rats by Oral Administration of 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine
Induction of Aberrant Crypt Foci in the Large Intestine of F344 Rats by Oral Administration of 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine
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口服 2-氨基-1-甲基-6-苯基咪唑并[4,5-b]吡啶诱导 F344 大鼠大肠异常隐窝病灶
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发表时间：
1991
期刊：
影响因子：
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通讯作者：
T. Sugimura
中科院分区：
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作者：
Satoru Takahashi;K. Ogawa;H. Ohshima;H. Esumi;N. Ito;T. Sugimura
以结肠异常隐窝（AC）作为癌前病变的标志物，研究了2-氨基-1-甲基-6-苯基咪唑[4，5-B]吡啶（PhIP）对大鼠结肠的致癌性。在实验第4周，每个结肠的AC病灶数量为1.3 ± 0.8;几乎是由2-氨基-6-甲基二吡啶并[1，2-a：3′，2 ′-d]咪唑（Glu-P-1）诱导的AC病灶水平的一半，Glu-P-1是一种已知的结肠致癌物。对照组大鼠未见AC。重复实验表明，通过PhIP给药诱导AC病灶是可重现的，并且在PhIP给药12周后观察到AC病灶数量显著增加（3.0 ±0.0）。PhIP诱导的大多数AC位于结肠远端。分布与Glu‐P‐1和1，2 ‐二甲基肼诱导的分布相似。这些数据表明，PhIP可能对大鼠结肠有致癌作用。
Carcinogenicity of 2‐amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP) to rat colon was investigated using the appearance of colonic aberrant crypt (AC), a preneoplastic lesion, as a marker. The number of AC foci per colon at experimental week 4 was 1.3 ± 0.8; almost half the level of AC foci induced by 2‐amino‐6‐methyIdipyrido[l,2‐a:3′,2′‐d]imidazole (Glu‐P‐1), which is a known colon carcinogen. No ACs were observed in rats of the control group. A repeat experiment showed that induction of AC foci by PhIP administration was reproducible and a significant increase in the number of AC foci, 3.0 ±0.0, was observed after 12 weeks of PhIP administration. The majority of ACs induced by PhIP were localized in the distal part of the colon. The distribution was similar to those induced by Glu‐P‐1 and 1,2‐dimethylhydrazine. Those data suggested that PhIP is possibly carcinogenic to rat colon.