Persistence of functional antibodies to group B streptococcal capsular polysaccharides following immunization with glycoconjugate vaccines
Persistence of functional antibodies to group B streptococcal capsular polysaccharides following immunization with glycoconjugate vaccines
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DOI：
10.1016/j.vaccine.2012.04.048
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发表时间：
2012-06-13
期刊：
影响因子：
5.5
通讯作者：
Baker, Carol J.
中科院分区：
文献类型：
--
作者：
Edwards, Morven S.;Lane, Heidi J.;Baker, Carol J.
在健康成人应答者中评估B组链球菌（CBS）糖结合疫苗诱导的荚膜多糖特异性IgG （CPS）的功能活性持续时间。从免疫后4周的峰值开始，opsonopha吞噬细胞活性显著下降，但在免疫后18个月至2年，每种CBS类型的CBS cfu/mL均保持了显著的功能活性，降低幅度超过1 log（10）。当CBS cps特异性IgG浓度下降时，尽管仍明显高于免疫前水平，但功能性抗体活性的持续存在表明，对该人群施用候选CBS糖缀合物可能具有长期保护作用。(C) 2012 Elsevier Ltd.版权所有。
The duration of functional activity of group B streptococcal (CBS) glycoconjugate vaccine-induced capsular polysaccharide-specific (CPS) IgG was evaluated among healthy adult responders. Opsonophagocytic activity declined significantly from a 4-week post-immunization peak, but substantial functional activity, exceeding 1 log(10) reduction in CBS cfu/mL, was retained at 18 months to 2 years post-immunization for each CBS type assessed. The persistence of functional antibody activity when CBS CPS-specific IgG concentrations decline, although remaining significantly higher than pre-immunization levels, suggests that long-term protection may be expected from candidate CBS glycoconjugates administered to this population. (C) 2012 Elsevier Ltd. All rights reserved.