Angiogenesis and vasculogenesis: Inducing the growth of new blood vessels and wound healing by stimulation of bone marrow-derived progenitor cell mobilization and homing
Angiogenesis and vasculogenesis: Inducing the growth of new blood vessels and wound healing by stimulation of bone marrow-derived progenitor cell mobilization and homing
复制标题
DOI：
10.1016/j.jvs.2007.02.068
复制
发表时间：
2007-06-01
影响因子：
4.3
通讯作者：
Velazquez, Omaida C.
中科院分区：
文献类型：
--
作者：
Velazquez, Omaida C.
在胚胎发育期间，脉管系统是最早形成的器官之一，负责通过提供氧气和营养物质以及清除废物来维持代谢稳态。正如人们所预料的那样，血管不仅对胚胎中的器官生长至关重要，而且对成人中受伤组织的修复也至关重要。血管生成（一个历史悠久的术语，在全球范围内指的是新血管的生长）的不平衡有助于许多恶性，炎症，缺血性，感染性，免疫和伤口愈合疾病的发病机制。本文综述了新血管生长在缺血性和糖尿病伤口愈合中的核心作用，并定义了描述伤口新生血管形成过程的最新命名法。现在有两个明确的，不同的，但相互关联的过程，形成出生后新的血管，血管生成和血管发生。回顾了最近关于血管发生的新数据，这些数据有望推动伤口愈合领域的发展。
During embryonic development, the vasculature is among the first organs to form and is in charge of maintaining metabolic homeostasis by supplying oxygen and nutrients and removing waste products. As one would expect, blood vessels are critical not only for organ growth in the embryo but also for repair of wounded tissue in the adult. An imbalance in angiogenesis (a time-honored term that globally refers to the growth of new blood vessels) contributes to the pathogenesis of numerous malignant, inflammatory, ischemic, infectious, immune, and wound-healing disorders. This review focuses on the central role of the growth of new blood vessels in ischemic and diabetic wound healing and defines the most current nomenclature that describes the neovascularization process in wounds. There are now two well-defined, distinct, yet interrelated processes for the formation of postnatal new blood vessels, angiogenesis, and vasculogenesis. Reviewed are recent new data on vasculogenesis that promise to advance the field of wound healing.