An assessment of health related quality of life using the child health and illness profile-adolescent edition in adolescents with chronic kidney disease due to underlying urological disorders
An assessment of health related quality of life using the child health and illness profile-adolescent edition in adolescents with chronic kidney disease due to underlying urological disorders
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DOI：
10.1016/j.juro.2007.04.008
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发表时间：
2007-08-01
影响因子：
6.6
通讯作者：
Furth, Susan L.
中科院分区：
文献类型：
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作者：
Dodson, Jennifer L.;Diener-West, Marie;Furth, Susan L.
目的：我们使用通用的健康相关生活质量量表检查了患有先天性泌尿系统疾病导致肾病的青少年的健康相关生活质量。然后，我们比较了结果，在青少年与医学肾脏疾病和人口为基础的normals.Materials和方法：儿童健康和疾病档案，青少年版113例10至18岁的慢性肾脏疾病。平均域和子域得分与泌尿系统疾病的青少年进行了比较，与医学肾脏疾病的青少年和人口为基础的normal.Results：队列包括一个潜在的诊断先天性泌尿系统异常（37例）或其他原因的肾脏疾病（76）的青少年。与其他因素引起的肾病青少年相比，先天性泌尿系统疾病青少年在儿童健康和疾病概况-青少年版活动受限子领域的得分在统计学上显著更好（平均值22.3 [SD 2.51 vs 20.4 [SD 5.01，p = 0.04）。与人群标准相比，患有先天性疾病的青少年在疾病领域的得分较低（平均值16.5，95% CI 14.2 - 18.9），但在风险领域更好（平均值25.9，95%CI 25.1至26.6）和家庭安全与健康子领域（平均值25.2，95% CI 23.7至26.6）。根据儿童健康和疾病概况-青少年版通用健康状况问卷的评估，与那些有潜在内科肾脏疾病的青少年相比，由于潜在先天性泌尿系统疾病而导致的肾脏疾病的青少年活动受限较少。除了在疾病领域的低评分外，与基于人群的规范相比，患有基础泌尿系统疾病的儿童在任何其他领域均无显著损害。
Purpose: We examined health related quality of life in adolescents with congenital urological disease causing kidney disease using a generic health related quality of life instrument. We then compared the results to those in adolescents with medical kidney disease and to population based norms.Materials and Methods: The Child Health and Illness Profile-Adolescent Edition was administered to 113 patients 10 to 18 years old with chronic kidney disease. Mean domain and subdomain scores for adolescents with urological disease were compared to those of adolescents with medical kidney disease and to population based norms.Results: The cohort included adolescents with an underlying diagnosis of congenital urological anomaly (37 patients) or other causes of kidney disease (76). Compared to adolescents with kidney disease caused by other factors, those with congenital urological disease scored statistically significantly better in the Child Health and Illness Profile-Adolescent Edition subdomain of Limitations of Activity (mean 22.3 [SD 2.51 vs 20.4 [SD 5.01, p = 0.04). Compared to population norms, adolescents with congenital disorders scored lower in the Disorders domain (mean 16.5, 95% CI 14.2 to 18.9) but better in the Risks domain (mean 25.9, 95% CI 25.1 to 26.6) and in the Home Safety and Health subdomain (mean 25.2, 95% CI 23.7 to 26.6).Conclusions: As assessed by the Child Health and Illness Profile-Adolescent Edition generic health status questionnaire, adolescents with kidney disease due to underlying congenital urological disease had fewer limitations of activity compared to those with underlying medical kidney disease. Except for low scores in the Disorders domain, children with underlying urological disease did not have significant impairments in any other domain compared to population based norms.