Transfer of clonidine and dexmedetomidine across the isolated perfused human placenta
Transfer of clonidine and dexmedetomidine across the isolated perfused human placenta
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DOI：
10.1111/j.1399-6576.1997.tb04685.x
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发表时间：
1997-02-01
影响因子：
2.1
通讯作者：
Vahakangas, K
中科院分区：
文献类型：
--
作者：
AlaKokko, TI;Pienimaki, P;Vahakangas, K
背景：将早期用作产科硬膜外镇痛辅助剂的α(2)受体激动剂clonidine与较新的α(2)选择性激动剂右美托咪定的胎盘转移进行比较。方法：经产妇同意，分娩后立即取足月胎盘，单胎盘子叶循环灌注2小时。在4个实验中，观察了可乐定或右美托咪定与参比化合物安替比林在母体循环中消失、在胎盘组织中积累以及在胎儿循环中出现的情况。结果：2 h时，右美托咪定在胎儿循环中的检出率为12.5 (SD 5.1)%，在灌注的胎盘子叶中检出率为48.1 (SD 20.3)%。胎儿循环中可乐定的平均浓度高于右美托咪定(1.90比0.56 nmol/l， P
Background: The placental transfer of the alpha(2) receptor agonist clonidine, earlier used as an adjuvant in obstetric epidural analgesia, was compared with the transfer of the newer and more alpha(2)-selective agonist dexmedetomidine.Methods: Term placentas were obtained immediately after delivery with maternal consent and a 2-hour recycling perfusion of a single placental cotyledon was performed. Disappearance from the maternal circulation, accumulation in placental tissue and appearance in the fetal circulation of clonidine or dexmedetomidine with the reference compound antipyrine were followed in 4 experiments for both drugs.Results: At 2 hours the percent dexmedetomidine found in the fetal circulation was 12.5 (SD 5.1)%, while 48.1 (SD 20.3)% was found in the perfused placental cotyledon. A higher mean clonidine than dexmedetomidine concentration was achieved in the fetal circulation (1.90 vs. 0.56 nmol/l, P