Protein S-100B as a serum marker of brain damage in severe head injury: preliminary results
Protein S-100B as a serum marker of brain damage in severe head injury: preliminary results
复制标题
DOI：
10.1007/pl00011944
复制
发表时间：
2000-10
影响因子：
2.8
通讯作者：
A. Raabe;V. Seifert
中科院分区：
文献类型：
--
作者：
A. Raabe;V. Seifert
本研究的目的是探讨S-100 B蛋白作为重型颅脑损伤后脑细胞损伤的血清标志物。83例重度颅脑损伤（格拉斯哥昏迷评分≤8分）患者纳入本前瞻性研究。入院后每24 h采集静脉血样本，检测S-100 B蛋白，最多连续10天。在6个月时使用格拉斯哥结局量表评估结局。在这项研究中，我们分析了25例患者6个月时的初步结果。结果不利的患者的S-100 B水平显著高于结果有利的患者。在预后良好的患者中，S-100 B的初始水平略有增加，在3至4天内恢复正常。在预后不良的患者中，初始水平明显升高，从第1天到第6天有下降的趋势。第6天后，血清S-100 B出现继发性升高，表明继发性脑细胞损伤。我们的初步结果表明，血清S-100 B蛋白可能是一个有前途的生化标志物，可以提供额外的信息，原发性脑损伤的程度和重型颅脑损伤后的结果预测。
The objective of our study was to investigate S-100B protein as a serum marker of brain cell damage after severe head injury. Eighty-three patients with severe head injury (Glasgow Coma Scale ≤8) were included in this prospective study. Venous blood samples for S-100B protein were taken after admission and every 24 h for a maximum of 10 consecutive days. Outcome was assessed at 6 months using the Glasgow Outcome Scale. In this study, we analysed the preliminary results from the outcomes of 25 patients at 6 months. Levels of S-100B were significantly higher in patients with unfavourable outcome compared to those with favourable outcome. In patients with favourable outcome, slightly increased initial levels of S-100B returned to normal within 3 to 4 days. In patients with unfavourable outcome, initial levels were markedly increased, with a tendency to decrease from day 1 to day 6. After day 6, there was a secondary increase in serum S-100B, indicating secondary brain cell damage. Our preliminary results suggest that serum S-100B protein might be a promising biochemical marker which may provide additional information on the extent of primary injury to the brain and the prediction of outcome after severe head injury.