Mustela vison ACE2 functions as a receptor for SARS-coronavirus.
Mustela vison ACE2 functions as a receptor for SARS-coronavirus.
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DOI：
10.1007/978-0-387-33012-9_90
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发表时间：
2006
影响因子：
--
通讯作者：
Wentworth DE
中科院分区：
文献类型：
--
作者：
Heller LK;Gillim-Ross L;Olivieri ER;Wentworth DE
2002-2003年，中国广东省爆发了严重急性呼吸系统综合征（SARS）。这次疫情随后影响了29个国家，导致8，096例SARS病例，其中774例死亡。2病原体被确定为以前未被识别的CoV，称为SARS-CoV。SARS-CoV的爆发可能是由人畜共患病传播引起的。虽然SARS-CoV是从几个物种中分离出来的，但其祖先的天然储存库仍有待发现。在迄今为止检查的动物中，SARS-CoV最常从喜马拉雅棕榈果子狸中分离出来，这些果子狸在广东和东南亚其他地区的活动物市场上出售。[3]果子狸在SARS爆发中扮演的角色尚不清楚。然而，从果子狸身上分离出的SARS冠状病毒似乎受到了强大的选择压力，并且在遗传上与爆发早期感染人类的病毒最相似。[4]在果子狸中复制的选择压力可能产生了更容易传播给人类的菌株。果子狸是一种食肉动物，属于裂足亚目。其他的裂足目动物包括浣熊狗、狗、猫、浣熊、臭鼬、雪貂（Mustela putorius）和水貂（Mustela vison）。在一家活畜市场的一只浣熊狗身上也检测到SARS冠状病毒样病毒。3. Fissipedia
In 2002–2003, there was an outbreak of severe acute respiratory syndrome (SARS) in Guangdong Province, China. This outbreak subsequently affected 29 countries and resulted in 8,096 cases of SARS, of which 774 were fatal. 2 The causative agent was determined to be a previously unrecognized CoV, which became known as SARS-CoV. The SARS-CoV outbreak likely resulted from zoonotic transmission. Although SARS-CoV was isolated from several species, the natural reservoir of its progenitor remains to be discovered. Of the animals examined to date, SARS-CoV was most frequently isolated from Himalayan palm civets, which are sold in live animal markets in Guangdong and in other regions of Southeast Asia. 3 The role palm civets played in the SARS outbreak is unclear. However, SARS-CoV-like viruses isolated from palm civets appeared to be under strong selective pressure and are genetically most similar to viruses infecting humans early in the outbreak. 4 The selective pressure of replication in palm civet may have generated strains that could be more easily transmitted to humans. Palm civets are carnivores in the suborder Fissipedia. Other Fissipedia include raccoon dog, dog, cat, raccoon, skunk, ferret (Mustela putorius), and mink (Mustela vison). SARS-CoV-like virus was also detected in a raccoon dog in a live animal market. 3 Furthermore, Fissipedia