LPS-Induced Cytokine Production in Human Monocytes and Macrophages
LPS-Induced Cytokine Production in Human Monocytes and Macrophages
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DOI：
10.1615/critrevimmunol.v31.i5.20
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发表时间：
2011-01-01
影响因子：
1.3
通讯作者：
Hauschildt, Sunna
中科院分区：
文献类型：
--
作者：
Rosso, Manuela;Heine, Holger;Hauschildt, Sunna
来自革兰氏阴性细菌的脂多糖（LPS）是已知的最有效的先天免疫激活刺激物之一。在此，我们回顾一下目前对 LPS 对人类单核细胞和巨噬细胞功能影响的认识。我们概述了 LPS 信号转导，重点关注 LPS 反应中的受体协同性和物种差异，以及酪氨酸磷酸化和赖氨酸乙酰化在信号转导中的作用。我们还回顾了 LPS 调节的转录，重点是染色质重塑和初级与次级转录控制机制。最后，我们回顾了人类单核细胞和巨噬细胞产生的 LPS 诱导细胞因子的调节和功能，包括 TNF α、IL-1 家族、IL-6、IL-8、IL-10 家族、IL-12 家族、IL-15 和 TGF β。
Lipopolysaccharide (LPS) from Gram-negative bacteria is one of the most potent innate immune-activating stimuli known. Here we review the current understanding of LPS effects on human monocyte and macrophage function. We provide an overview of LPS signal transduction with attention given to receptor cooperativity and species differences in LPS responses, as well as the role of tyrosine phosphorylation and lysine acetylation in signalling. We also review LPS-regulated transcription, with emphasis on chromatin remodeling and primary versus secondary transcriptional control mechanisms. Finally, we review the regulation and function of LPS-inducible cytokines produced by human monocytes and macrophages including TNF alpha, the IL-1 family, IL-6, IL-8, the IL-10 family, the IL-12 family, IL-15 and TGF beta.