Potential Role of miRNAs as Theranostic Biomarkers of Epilepsy.
Potential Role of miRNAs as Theranostic Biomarkers of Epilepsy.
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DOI：
10.1016/j.omtn.2018.09.008
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发表时间：
2018-12-07
期刊：
影响因子：
--
通讯作者：
Castiglioni I
中科院分区：
文献类型：
--
作者：
Cava C;Manna I;Gambardella A;Bertoli G;Castiglioni I
癫痫包括一组以产生癫痫发作的持久倾向为特征的脑疾病。虽然家族性癫痫具有遗传成分和遗传性，但大多数非家族性癫痫的病因学没有已知的相关基因突变。在癫痫中，最近的表观遗传学概况强调了microRNA在其病理生理学中的可能作用。特别是，分子谱鉴定了动物模型和人类组织的癫痫海马中大量改变的microRNA（miRNAs）。在这篇综述中，分析了不同癫痫动物模型的分子特征，我们确定了一组20种在不同癫痫动物模型中通常发生改变的miRNAs。由于新出现的证据强调了动物模型组织和人类样本的特征之间的重叠性很差，我们将分析重点放在人类生物流体中循环的miRNA上，其在癫痫标志中起主要作用，并且我们鉴定了一组8种诊断性循环miRNA。我们讨论了这8种miRNA在癫痫标志中的功能作用。其中一些也被提出作为癫痫治疗的治疗分子，揭示了miRNA作为癫痫治疗诊断分子的巨大潜力。
Epilepsy includes a group of disorders of the brain characterized by an enduring predisposition to generate epileptic seizures. Although familial epilepsy has a genetic component and heritability, the etiology of the majority of non-familial epilepsies has no known associated genetic mutations. In epilepsy, recent epigenetic profiles have highlighted a possible role of microRNAs in its pathophysiology. In particular, molecular profiling identifies a significant number of microRNAs (miRNAs) altered in epileptic hippocampus of both animal models and human tissues. In this review, analyzing molecular profiles of different animal models of epilepsy, we identified a group of 20 miRNAs commonly altered in different epilepsy-animal models. As emerging evidences highlighted the poor overlap between signatures of animal model tissues and human samples, we focused our analysis on miRNAs, circulating in human biofluids, with a principal role in epilepsy hallmarks, and we identified a group of 8 diagnostic circulating miRNAs. We discussed the functional role of these 8 miRNAs in the epilepsy hallmarks. A few of them have also been proposed as therapeutic molecules for epilepsy treatment, revealing a great potential for miRNAs as theranostic molecules in epilepsy.
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影响因子：
5.6
作者：
Cava C;Colaprico A;Bertoli G;Graudenzi A;Silva TC;Olsen C;Noushmehr H;Bontempi G;Mauri G;Castiglioni I
通讯作者：
Castiglioni I
影响因子：
--
作者：
Drusco A;Bottoni A;Laganà A;Acunzo M;Fassan M;Cascione L;Antenucci A;Kumchala P;Vicentini C;Gardiman MP;Alder H;Carosi MA;Ammirati M;Gherardi S;Luscrì M;Carapella C;Zanesi N;Croce CM
通讯作者：
Croce CM
影响因子：
3.5
作者：
Duan, Ranhui;Pak, ChangHui;Jin, Peng
通讯作者：
Jin, Peng
影响因子：
3.7
作者：
Avansini SH;de Sousa Lima BP;Secolin R;Santos ML;Coan AC;Vieira AS;Torres FR;Carvalho BS;Alvim MK;Morita ME;Yasuda CL;Pimentel-Silva LR;Dogini DB;Rogerio F;Cendes F;Lopes-Cendes I
通讯作者：
Lopes-Cendes I
影响因子：
3.2
作者：
Chen T;Giri M;Xia Z;Subedi YN;Li Y
通讯作者：
Li Y