Partial splenic embolization in five children with hypersplenism: Effects of reduced-volume embolization on efficacy and morbidity
Partial splenic embolization in five children with hypersplenism: Effects of reduced-volume embolization on efficacy and morbidity
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DOI：
10.1148/radiology.209.3.9844678
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发表时间：
1998-12-01
期刊：
影响因子：
19.7
通讯作者：
Sokol, RJ
中科院分区：
文献类型：
--
作者：
Harned, RK;Thompson, HR;Sokol, RJ
目的：评价部分脾栓塞术（PSE）中减少梗死脾脏体积治疗儿童脾功能亢进的效果。材料与方法：对5例脾功能亢进患儿进行30%-40%脾体积的栓塞。结果与之前对 17 名儿童进行 70%-80% PSE 的研究进行了比较。结果：手术后的住院时间从 16.0 天 +/- 8.0 减少到 6.6 天 +/- 5.6。发热期从 15.0 天 +/- 8.1 减少到 5.0 天 +/- 6.6。白细胞计数峰值为 8,300/mm(3) +/- 4,600(8.3 x 10(9)/L +/- 4.6)，而早期研究中的峰值白细胞计数为 19,400/mm(3) +/- 7,800 (19.4 x 10(9)/L +/- 7.8)。峰值血小板计数为 153,000/mm(3) +/- 65,000 (153 x 10(9)/L +/- 65) 与 636,000/mm(3) +/- 406,000 (636 x 10(9)/L +/- 406)。平均随访 14 个月后的血小板计数为 70,000/mm(3) I：7,000 (70 x 10(9)/L +/- 7)，而平均随访 45 个月后血小板计数为 230,000/mm(3) +/- 62,000 (230 x 10(9)/L +/- 62)。静脉曲张出血的频率从每年 3.5 次减少到 0.5 次。鼻出血的频率从每月 30 次减少到 15 次。结论：减少栓塞体积可降低发病率。所有患者的血小板计数均维持在基线以上，并且没有患者需要重复栓塞。
PURPOSE: To evaluate the effects of reducing the volume of spleen infarcted during partial splenic embolization (PSE) for treatment of hypersplenism in children.MATERIALS AND METHODS:Five children with hypersplenism underwent embolization of 30%-40% of the splenic volume. The results were compared with those of a previous study of 70%-80% PSE performed in 17 children.Results: The hospital stay after the procedure was reduced from 16.0 days +/- 8.0 to 6.6 days +/- 5.6. The febrile period decreased from 15.0 days +/- 8.1 to 5.0 days +/- 6.6. The peak white blood cell count was 8,300/mm(3) +/- 4,600(8.3 x 10(9)/L +/- 4.6) versus 19,400/mm(3) +/- 7,800 (19.4 x 10(9)/L +/- 7.8) in the earlier study. The peak platelet count was 153,000/mm(3) +/- 65,000 (153 x 10(9)/L +/- 65) versus 636,000/mm(3) +/- 406,000 (636 x 10(9)/L +/- 406). The platelet count after a mean follow-up of 14 months was 70,000/mm(3) I: 7,000 (70 x 10(9)/L +/- 7) versus 230,000/mm(3) +/- 62,000 (230 x 10(9)/L +/- 62) after a mean follow-up of 45 months. The frequency of variceal hemorrhage decreased from 3.5 to 0.5 episodes per year. The frequency of epistaxis decreased from 30 to 15 episodes per month.CONCLUSION: Reduced-volume embolization decreased morbidity. All patients maintained a platelet count above baseline, and no patient required repeat embolization.