Frequency of testing for detecting visual field progression
Frequency of testing for detecting visual field progression
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DOI：
10.1136/bjo.86.5.560
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发表时间：
2002-05-01
影响因子：
4.1
通讯作者：
Crabb, DP
中科院分区：
文献类型：
--
作者：
Gardiner, SK;Crabb, DP
目的：探讨测试频率对使用逐点线性回归（PLR.Methods）确定视野进展的影响：开发了一种“虚拟眼”来模拟眼睛中给定点随时间推移的一系列敏感性。用户可以输入点的实际行为（例如，稳定或稳定恶化），然后添加可配置的噪声量以产生随时间变化的真实系列。与使用患者数据相比，这样做的优点是眼睛的实际状态是已知的。使用不同的测试频率生成系列，并将从每个系列中做出的诊断与眼睛的真实状态进行比较。如果该系列的II回归线显示每年至少1 A的恶化，则该点被诊断为进展，在1%水平下显著。从这些结果中，产生显示正确或错误诊断为进展的点的数量的图。随着虚拟眼以2 dB/年的速率恶化，结果发现，这一点是特伦特决心进步更快时，更多的测试进行了每年。随着一个稳定的虚拟眼，它被发现，增加测试的频率增加了被错误地标记为在第一个3年的testing.Conclusions进展的系列的数量：随着测试的频率增加，PLR的灵敏度增加。然而，特异性降低;可能意味着治疗中更多不必要的变化。每年进行三次检测，在灵敏度和特异性之间提供了良好的折衷。
Aims: To investigate the effect of frequency of testing on the determination of visual field progression using pointwise linear regression (PLR).Methods: A "virtual eye" was developed to simulate series of sensitivities over time at a given point in the eye. The user can input the actual behaviour of the point (for example, stable or deteriorating steadily), and then a configurable amount of noise is added to produce a realistic series over time. The advantage of this over using patient data is that the actual status of the eye is known. Series were generated using different frequencies of testing, and the diagnosis that would have been made from each series was compared with the true status of the eye. A point was diagnosed as progressing if the I I regression line for the series showed a deterioration of at least 1 A per year, significant at the 1% level, From these results, graphs were produced showing the number of points correctly or incorrectly diagnosed as progressing,Results: With the virtual eye deteriorating of a rate of 2 dB/year, it was found that the point was Trent determined to be progressing quicker when more tests were carried out each year. With a stable virtual eye, it was found that increasing the frequency of testing increased the number of series that were falsely labelled as progressing during the first 3 years of testing.Conclusions: As the frequency of testing increases, the sensitivity of PLR increases. However, the specificity decreases; possibly meaning more unnecessary changes in treatment. Three tests per year provide a good compromise between sensitivity and specificity.