Correlation of blood levels of soluble vascular cell adhesion molecule-1 with disease activity in systemic lupus erythematosus and vasculitis.
Correlation of blood levels of soluble vascular cell adhesion molecule-1 with disease activity in systemic lupus erythematosus and vasculitis.
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系统性红斑狼疮和血管炎中可溶性血管细胞粘附分子-1的血液水平与疾病活动度的相关性。
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发表时间：
1994
期刊：
影响因子：
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通讯作者：
Paul Emery
中科院分区：
文献类型：
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作者：
B. A. Janssen;R. Luqmani;Caroline Gordon;I. Hemingway;P. Bacon;A. Gearing;Paul Emery
可溶性粘附分子的水平已被证明可以反映其体外细胞表面表达，因此可以提供炎症部位表面表达的有用替代标志物。采用酶联免疫吸附法（ELISA）测定SLE患者不同活动期血清细胞间粘附分子-1（ICAM-1）、血管细胞粘附分子-1（VCAM-1）和E-选择素（E-Select）水平。可溶性VCAM-1水平与SLE患者的疾病活动性相关，活动期显著高于非活动期（P = 0.003），并随临床缓解而正常化。相比之下，在血管炎患者中，尽管sVCAM-1水平在活动性疾病中升高，但在非活动性疾病中下降但未恢复正常，这表明治疗可能是抑制临床表现，而不是针对潜在的致病机制。可溶性ICAM-1和E-选择素水平不反映SLE或血管炎的疾病活动性。
Levels of soluble adhesion molecules have been shown to reflect their cell surface expression in vitro, and thus may provide a useful surrogate marker of surface expression at inflammatory sites. In patients with SLE and vasculitis, serum levels of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-Selection were determined by ELISA during different stages of disease activity. Levels of soluble(s) VCAM-1 correlated with disease activity in patients with SLE, being significantly higher during active compared with inactive disease (P = 0.003), and normalizing with clinical remission. By contrast, in patients with vasculitis, although sVCAM-1 levels were elevated in active disease, they fell but did not normalize in inactive disease, suggesting that treatment may be suppressing the clinical manifestations rather than targeting the underlying pathogenic mechanism. Soluble ICAM-1 and E-Selectin levels did not relfect disease activity in either SLE or vasculitis.