Trehalose as a "chemical chaperone": fact and fantasy.
Trehalose as a "chemical chaperone": fact and fantasy.
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发表时间：
2007
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通讯作者：
J. Crowe
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作者：
J. Crowe
海藻糖是葡萄糖的一种二糖，在自然界中自然干燥的各种生物体中都存在高浓度的葡萄糖。许多年前，我们报道了这种分子在干燥状态下具有稳定细胞膜和蛋白质的非凡能力。一种稳定海藻糖的机制迅速出现，而且关于海藻糖是一种普遍的保护剂和化学伴侣的神话也足够吸引人。这方面的许多说法可以用目前已知的这种有趣的糖的物理性质来解释。新出现的情况是，这些特性可能使其在干燥状态下稳定完整细胞方面异常有用。
Trehalose is a disaccharide of glucose that is found at high concentrations in a wide variety of organisms that naturally survive drying in nature. Many years ago we reported that this molecule has the remarkable ability to stabilize membranes and proteins in the dry state. A mechanism for the stabilization rapidly emerged, and it was sufficiently attractive that a myth grew up about trehalose as a universal protectant and chemical chaperone. Many of the claims in this regard can be explained by what is now known about the physical properties of this interesting sugar. It is emerging that these properties may make it unusually useful in stabilizing intact cells in the dry state.