An osmium-191/iridium-191m radionuclide generator using an oxalato osmate parent complex.
An osmium-191/iridium-191m radionuclide generator using an oxalato osmate parent complex.
复制标题
使用草酸锇酸母体复合物的 osmium-191/iridium-191m 放射性核素发生器。
DOI：
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发表时间：
1987
影响因子：
9.3
通讯作者：
K. S. Lim
中科院分区：
文献类型：
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作者：
A. Packard;S. Treves;G. M. O’Brien;K. S. Lim
研制了一种新的锇-191/铱-191m（191 Os/191 mIr）放射性核素发生器，当用0.001M草酸和0.9%（生理）盐水溶液洗脱时，它具有高的191 mIr产率（大于20%/ml）和低的191 Os穿透（小于5 × 10（-4）%/ml）。这是第一个191 Os/191 mIr发生器，结合了高191 mIr产量，极低的191 Os穿透和注入前不需要缓冲的优点。这些性能的改善是通过使用螯合物transdioxobisodiosmate（VI）作为发生器上的母体复合物来实现的。与使用锝-99m（99 mTc）进行的相同研究相比，更高产额和更低穿透的组合的临床结果是估计的患者辐射剂量降低了100倍，并且可注射的放射性核素使发生器更容易使用。对该发生器进行的急性和亚急性毒性研究表明，没有可归因于该发生器的不良反应。
A new osmium-191/iridium-191m (191Os/191mIr) radionuclide generator has been developed that offers high 191mIr yield (greater than 20%/ml) and low 191Os breakthrough (less than 5 X 10(-4)%/ml) when eluted with a solution of 0.001 M oxalic acid and 0.9% (normal) saline. This is the first 191Os/191mIr generator that combines the advantages of high 191mIr yield, extremely low 191Os breakthrough, and an eluate that does not require buffering prior to injection. These improvements in performance were accomplished through use of the chelate transdioxobisoxalatoosmate(VI) as the parent complex on the generator. The clinical result of the combination of higher yield and lower breakthrough is a 100-fold decrease in the estimated patient radiation dose compared with the same study performed with technetium-99m (99mTc), and the injectable eluate makes the generator easier to use. Acute and subacute toxicity studies performed on this generator eluate have shown no adverse effects attributable to the eluate.