Wiring optimization can relate neuronal structure and function
Wiring optimization can relate neuronal structure and function
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DOI：
10.1073/pnas.0506806103
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发表时间：
2006-03-21
影响因子：
11.1
通讯作者：
Chklovskii, DB
中科院分区：
文献类型：
--
作者：
Chen, BL;Hall, DH;Chklovskii, DB
我们的假设是，在动物体内放置神经元可以最大限度地减少连接成本，因为功能限制是由突触连接指定的。利用新编译的秀丽隐杆线虫接线图，我们求解了279个非咽部神经元的最佳布局。在最优布局中，大多数神经元位于其实际位置附近，这表明布线最小化是一个重要因素。然而，一些神经元表现出与“最佳”位置的强烈偏差。我们认为，与轴突引导和命令神经元功能有关的生物学因素有助于这些偏差。我们通过提出一个改进的布线成本函数来捕捉这些因素。
We pursue the hypothesis that neuronal placement in animals minimizes wiring costs forgiven functional constraints, as specified by synaptic connectivity. Using a newly compiled version of the Caenorhabditis elegans wiring diagram, we solve for the optimal layout of 279 nonpharyngeal neurons. In the optimal layout, most neurons are located close to their actual positions, suggesting that wiring minimization is an important factor. Yet some neurons exhibit strong deviations from "optimal" position. We propose that biological factors relating to axonal guidance and command neuron functions contribute to these deviations. We capture these factors by proposing a modified wiring cost function.