Icariin Improves Age-Related Testicular Dysfunction by Alleviating Sertoli Cell Injury via Upregulation of the ERα/Nrf2-Signaling Pathway
Icariin Improves Age-Related Testicular Dysfunction by Alleviating Sertoli Cell Injury via Upregulation of the ERα/Nrf2-Signaling Pathway
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淫羊藿苷通过上调 ERα/Nrf2 信号通路减轻支持细胞损伤，从而改善与年龄相关的睾丸功能障碍
DOI：
10.3389/fphar.2020.00677
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发表时间：
2020-05
影响因子：
5.6
通讯作者：
Ding Yuan
中科院分区：
文献类型：
--
作者：
Haixia Zhao;Xu You;Qian Chen;Siqi Yang;Qiongyan Ma;Yumin He;Chaoqi Liu;Yaoyan Dun;Jie Wu;Changcheng Zhang;Ding Yuan
Sertoli cells play crucial roles in spermatogenesis and are impaired by aging. Icariin, a flavonoid from Epimedium, has been reported to exhibit anti-aging effects and improve testicular dysfunction in the clinical setting. However, whether icariin improves age-related degeneration of testicular function via protection from Sertoli cell injury remains unclear. In the present study, we evaluated the protective effect of icariin on Sertoli cell injury and explored the possible mechanism(s) in vivo and in vitro. Dietary administration of icariin for 4 months significantly ameliorated the age-related decline in testicular function by increasing testicular and epididymal weights and indices, sperm count and sperm viability, testicular testosterone and estradiol concentrations, and seminiferous tubule diameters and heights. In addition, icariin protected age-related Sertoli cells from injury as evidenced by an analysis of Sertoli cell number, ultrastructure, and function. Such changes were accompanied by upregulation of ERα and Nrf2 signaling in Sertoli cells. Parallel in vitro studies also demonstrated that icariin inhibited untoward effects on the TM4 mouse Sertoli cell line with concomitant upregulation of ERα and Nrf2 signaling. Conversely, ERα siRNA reversed icariin-mediated protection of Sertoli cell injury. Our data suggest that icariin effectively ameliorates age-related degeneration of testicular function by alleviating Sertoli cell injury via the ERα/Nrf2 signal-transduction pathway. Thus, mitigating Sertoli cell damage via the ERα/Nrf2 signaling pathway likely represents a promising strategy for the prevention of age-related testicular dysfunction.
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DOI：
10.1186/s12979-017-0108-1
发表时间：
2018
期刊：
Immunity & ageing : I & A
影响因子：
--
作者：
Trovato Salinaro A;Pennisi M;Di Paola R;Scuto M;Crupi R;Cambria MT;Ontario ML;Tomasello M;Uva M;Maiolino L;Calabrese EJ;Cuzzocrea S;Calabrese V
通讯作者：
Calabrese V
雌激素受体和 PI3K/Akt 信号通路参与 S-(-) 雌马酚诱导的内皮细胞 Nrf2/ARE 激活
影响因子：
3.7
作者：
Zhang T;Liang X;Shi L;Wang L;Chen J;Kang C;Zhu J;Mi M
通讯作者：
Mi M
五子衍宗方通过内质网应激抑制衰老大鼠生殖细胞凋亡对睾丸功能障碍的保护作用
影响因子：
2.4
作者：
Haixia Zhao;Na Ma;Zhaoqi Liu;Ting wang;Chengfu Yuan;Yumin He;Yaoyan Dun;Zhiyong Zhou;Ding Yuan;Changcheng Zhang
通讯作者：
Changcheng Zhang
影响因子：
7.7
作者：
Li, Dianrong;Meng, Lingjun;Wang, Xiaodong
通讯作者：
Wang, Xiaodong
影响因子：
--
作者：
Han, Yibing;Feng, Huai L.;Haines, Christopher J.
通讯作者：
Haines, Christopher J.