Immunomodulatory therapy in the management of viral infections in patients with HIV infection
Immunomodulatory therapy in the management of viral infections in patients with HIV infection
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DOI：
10.1067/mjd.2000.107810
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发表时间：
2000-07-01
影响因子：
13.8
通讯作者：
Conant, MA
中科院分区：
文献类型：
--
作者：
Conant, MA
人类免疫缺陷病毒（HIV）通过感染淋巴细胞并逐渐破坏免疫系统的关键调节细胞和效应细胞而引起疾病，使患者易受许多细菌、真菌和病毒感染。面部疱疹（单纯疱疹病毒-1 [HSV-1]）、生殖器疱疹（HSV-2）、疱疹检测仪（水痘试验病毒），口腔毛状白斑（EB病毒）、卡波西肉瘤（HHV-8）、传染性软疣、尖锐湿疣（人乳头瘤病毒[HPV-6，HPV-11]），足底疣（HPV-1），面部疣和扁平疣（HPV-5）是HIV感染患者中最常见的一些皮肤病毒性疾病。两种免疫调节剂，咪喹莫特（Aldara），被证明是安全和有效的生殖器疣的管理，阿利维A酸凝胶，被证明是安全和有效的治疗卡波西肉瘤，可能提供一个新的治疗方法来治疗皮肤病毒性疾病。有强有力的科学依据表明，咪喹莫特和阿利维A酸凝胶可用于治疗已显示对免疫调节药物有反应的各种皮肤病毒性疾病。这代表了在感染部位治疗皮肤病毒性疾病的治疗范例中的新方法。
Human immunodeficiency virus (HIV) causes disease by infecting lymphocytes and progressively destroying critical regulatory and effector cells of the immune system, leaving patients vulnerable to a number of bacterial, fungal, and viral infections. Facial herpes (herpes simplex virus-1 [HSV-1]), genital herpes (HSV-2), herpes tester (varicella tester virus), oral hairy leukoplakia (Epstein-Barr virus), Kaposi's sarcoma (HHV-8), molluscum contagiosum, condyloma acuminata (human papillomavirus [HPV-6, HPV-11]), plantar warts (HPV-1), and facial warts and flat warts (HPV-5) are some of the cutaneous viral diseases most commonly seen in HIV-infected patients. Two immunomodulatory agents, imiquimod (Aldara), shown to be safe and effective in the management of genital warts, and alitretinoin gel, shown to be safe and effective in the treatment of Kaposi's sarcoma, may offer a new therapeutic approach to treatment of cutaneous viral diseases. There is a strong scientific rationale to suggest that imiquimod and alitretinoin gel may be useful in the treatment of a variety of cutaneous viral diseases that have been shown to respond to immunomodulatory drugs. This represents a new approach in the therapeutic treatment paradigm for treatment of cutaneous viral diseases at their site of infection.