A novel cognitive assessment paradigm to detect Pre-mild cognitive impairment (PreMCI) and the relationship to biological markers of Alzheimer's disease
A novel cognitive assessment paradigm to detect Pre-mild cognitive impairment (PreMCI) and the relationship to biological markers of Alzheimer's disease
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DOI：
10.1016/j.jpsychires.2017.08.015
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发表时间：
2018-01-01
影响因子：
4.8
通讯作者：
Cardenas, Karen
中科院分区：
文献类型：
--
作者：
Crocco, Elizabeth A.;Loewenstein, David A.;Cardenas, Karen
目的：一些老年人在正式的认知测试中得分正常，但临床表现出怀疑认知能力下降。尽管不符合轻度认知障碍（MCI）的全部标准，但这些PreMCI状态会增加进展为阿尔茨海默病（AD）的风险。这项研究解决了迫切需要确定对PreMCI敏感的认知测量，并与神经变性的脑生物标志物相关。方法：参与者包括49名老年人，他们的临床病史提示认知能力下降，但在一系列神经心理学测量中得分正常，因此不符合MCI的正式标准。这些PreMCI参与者的表现与117名认知正常（CN）的老年人在lasi - l中的表现进行了比较，lasi - l是一项认知压力测试，用于评估从主动语义干扰效应（frPSI）中恢复的失败。最后，其中一部分人进行了基于核磁共振扫描的体积分析。结果：与CN组相比，PreMCI参与者表现出更大的LASSI-L缺陷，特别是在第一psi和延迟回忆方面。在MRI测量上没有观察到差异。在控制错误发现率（FDR）的情况下，frPSI与下侧脑室扩张增加以及海马、楔前叶、上顶叶区和其他AD易发区域的MRI体积减小有关。相比之下，其他lasi - l指数和标准记忆测试与体积结果无关。结论：尽管在传统的记忆测量中表现相当，但frPSI在PreMCI和CN老年人之间具有区别，并且与许多AD相关的大脑区域的脑容量减少有关。(C) 2017年Elsevier Ltd.出版
Objective: A number of older adults obtain normal scores on formal cognitive tests, but present clinical concerns that raise suspicion of cognitive decline. Despite not meeting full criteria for Mild Cognitive Impairment (MCI), these PreMCI states confer risk for progression to Alzheimer's disease (AD). This investigation addressed a pressing need to identify cognitive measures that are sensitive to PreMCI and are associated with brain biomarkers of neurodegeneration.Method: Participants included 49 older adults with a clinical history suggestive of cognitive decline but normal scores on an array of neuropsychological measures, thus not meeting formal criteria for MCI. The performance of these PreMCI participants were compared to 117 cognitively normal (CN) elders on the LASSI-L, a cognitive stress test that uniquely assesses the failure to recover from proactive semantic interference effects (frPSI). Finally, a subset of these individuals had volumetric analyses based on MRI scans.Results: PreMCI participants evidenced greater LASSI-L deficits, particularly with regards to frPSI and delayed recall, relative to the CN group. No differences on MRI measures were observed. Controlling for false discovery rate (FDR), frPSI was uniquely related to increased dilatation of the inferior lateral ventricle and decreased MRI volumes in the hippocampus, precuneus, superior parietal region, and other AD prone areas. In contrast, other LASSI-L indices and standard memory tests were not related to volumetric findings.Conclusions: Despite equivalent performance on traditional memory measures, the frPSI distinguished between PreMCI and CN elders and was associated with reductions in brain volume in numerous AD relevant brain regions. (C) 2017 Published by Elsevier Ltd.