A randomized, placebo-controlled pilot study of patients with spontaneous intraventricular haemorrhage treated with intraventricular thrombolysis
A randomized, placebo-controlled pilot study of patients with spontaneous intraventricular haemorrhage treated with intraventricular thrombolysis
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DOI：
10.1016/j.jocn.2011.09.030
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发表时间：
2012-07-01
影响因子：
2
通讯作者：
Wang, Ernest
中科院分区：
文献类型：
--
作者：
King, Nicolas K. K.;Lai, Jin Li;Wang, Ernest
自发性脑出血（ICH）后发生的脑室内出血（IVH）是死亡的独立危险因素。研究了使用脑室内尿激酶（Uk）来减少脑室内血凝块体积并改善结果。招募需要脑室外引流的 IVH 患者并随机参加双盲安慰剂对照研究。对收集的脑脊液 (CSF) 血红蛋白 (Hb) 和连续 CT 扫描进行评估。研究结果为：感染率、在重症监护室的住院时间、生存率、美国国立卫生研究院卒中量表评分；并修改了Rankin量表分数。我们的结果显示，与安慰剂相比，接受 Uk 治疗的患者的引流脑脊液 Hb 浓度和血块溶解率均有所增加。其他结果指标没有发现差异，但英国治疗组的死亡率有降低的趋势。因此，脑室内 Uk 可以更快地解决 IVH，并且没有不良事件。 (C) 2011 Elsevier Ltd. 保留所有权利。
Intraventricular hemorrhage (IVH) occurring after spontaneous intracerebral hemorrhage (ICH) is an independent risk factor for mortality. The use of intraventricular urokinase (Uk) to reduce intraventricular blood clot volume and improve outcome was investigated. Patients with IVH requiring external ventricular drainage were recruited and randomized into a double-blind placebo controlled study. Assessments of collected cerebrospinal fluid (CSF) haemoglobin (Hb) and serial CT scans were performed. The study outcomes were: infection rates, length of stay in the intensive care unit, survival, National Institutes of Health Stroke Scale score; and modified Rankin Scale scores. Our results showed an increase in both the drained CSF Hb concentration in patients treated with Uk compared to placebo and in the rate of resolution clot volume. No differences were found in the other outcome measures but there was a trend towards lowered mortality in the group treated with Uk. Therefore, intraventricular Uk resulted in faster resolution of IVH with no adverse events. (C) 2011 Elsevier Ltd. All rights reserved.