Locus coeruleus noradrenergic lesions attenuate intraoral intake
Locus coeruleus noradrenergic lesions attenuate intraoral intake
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DOI：
10.1097/00001756-200110080-00023
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发表时间：
2001-10-08
期刊：
影响因子：
1.7
通讯作者：
Johnson, AE
中科院分区：
文献类型：
--
作者：
Ammar, AA;Södersten, P;Johnson, AE
雄性大鼠腹腔注射DSP-4可不同程度地降低整个大脑的去甲肾上腺素（NE）水平，下丘脑室旁核降低66.7%。口服输注蔗糖的摄入量减少了14天，但每日颗粒摄入量在注射后5天内恢复。脑室内NE恢复DSP-4损伤大鼠口内蔗糖摄入量，而不影响对照组。脑室内输注神经肽Y（NPY）可减少对照组大鼠的口内摄入量，但对DSP-4损伤大鼠无影响。在DSP-4处理的大鼠中，NPY显著抑制口内摄入，DSP-4处理的大鼠也接受NE。这些数据证实了研究表明，神经肽Y减少消费性摄食行为，并建议，这种抑制涉及上升的去甲肾上腺素能投射从蓝斑。NeuroReport 12：3095-3099（C）2001 Lippincott威廉姆斯和威尔金斯。
I.p. injections of DSP-4 in male rats decreased norepinephrine (NE) levels to varying degrees throughout the brain with 66.7% reductions in the hypothalamic paraventricular nucleus. Intake of intraorally infused sucrose was reduced for 14 days but daily pellet intake recovered within 5 days post-injection. Intraventricular NE restored intraoral sucrose intake in DSP-4-lesioned rats without affecting controls. Intraventricular infusion of neuropeptide Y (NPY) reduced intraoral intake in controls but had no effect in DSP-4-lesioned rats. NPY markedly inhibited intraoral intake in DSP-4-treated rats that also received NE. These data confirm studies showing that NPY decreases consummatory ingestive behavior and suggest that this inhibition involves ascending noradrenergic projections from locus coeruleus. NeuroReport 12:3095-3099 (C) 2001 Lippincott Williams & Wilkins.