Selective loss of the photopic negative response in patients with optic nerve atrophy
Selective loss of the photopic negative response in patients with optic nerve atrophy
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DOI：
10.1001/archopht.122.3.341
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发表时间：
2004-03-01
影响因子：
--
通讯作者：
Tazawa, Y
中科院分区：
文献类型：
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作者：
Gotoh, Y;Machida, S;Tazawa, Y
目的：目的：探讨视神经萎缩患者明视负反应（PhNR）的改变。方法：对10例因压迫、外伤或炎症引起的视神经萎缩患者进行检查。男6例，女4例，平均年龄52.4岁。10名年龄匹配的对照受试者进行了检查，与相同的协议。全视野视网膜电图;结果：患眼的视杆电图、最大电图、视锥电图和30 Hz闪烁电图的振幅与对侧健眼或对照眼的相应波的振幅无明显差异。相比之下，受累眼的PhNR振幅显著小于对侧（P= 0.005）或对照眼（P
Objective: To determine how the photopic negative response (PhNR) is altered in patients with optic nerve atrophy.Methods: Ten patients with optic nerve atrophy induced by compression, trauma, or inflammation were examined. There were 6 men and 4 women with a mean age of 52.4 years. Ten age-matched control subjects were examined with the same protocol. Full-field electroretinograms; were recorded, and the retinal nerve fiber layer thickness surrounding the optic nerve head was measured by means of optical coherence tomography.Results: The amplitudes of the rod, maximum, cone, and 30-Hz flicker electroretmograms; of the affected eyes were not different from those of the corresponding waves of the contralateral unaffected eyes or control eyes. In contrast, the amplitude of the PhNR was significantly smaller in the affected eyes than in the contralateral (P=.005) or control (P