Sequential pericyclic reaction of ene-diallenes: An efficient approach to the steroid skeleton
Sequential pericyclic reaction of ene-diallenes: An efficient approach to the steroid skeleton
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DOI：
10.1021/ol0525720
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发表时间：
2006-01-05
期刊：
影响因子：
5.2
通讯作者：
Mukai, C
中科院分区：
文献类型：
--
作者：
Kitagaki, S;Ohdachi, K;Mukai, C
通过串联双[2,3]-异位重排/6 -电环反应/分子内[4 + 2]环加成顺序，实现了无环烯-双（丙炔醇）多环芳烃体系的一锅构建。本方法可方便地合成甾体化合物。
The one-pot construction of polycyclic aromatic systems from acyclic ene-bis(propargyl alcohols) was achieved through a tandem dual [2,3]-sigmatropic rearrangement/6 pi-electrocyclic reaction/intramolecular [4 + 2] cycloaddition sequence. A steroidal compound was conveniently synthesized using the present method.