Electrophysiological evidence that ethanol alters function of medial septal area without affecting lateral septal function.
Electrophysiological evidence that ethanol alters function of medial septal area without affecting lateral septal function.
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发表时间：
1990-04
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通讯作者：
B. Givens;G. Breese
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文献类型：
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作者：
B. Givens;G. Breese
证据是在这个手稿提供了乙醇直接作用于神经元在内侧间隔区（MSA）。首先，我们对自由运动大鼠MSA神经元的电生理特征进行了表征，发现与氨基甲酸乙酯麻醉大鼠的电生理特征相似，但与水合氯醛麻醉大鼠的电生理特征不同。因此，用聚氨酯来评价乙醇对麻醉大鼠的影响。乙醇影响MSA神经功能的结论是基于电生理数据，即乙醇（0.75-3.0 g/kg / p）以剂量相关的方式抑制了脲麻醉和未麻醉大鼠中隔细胞的神经放电。在抑制放电速率的同时，乙醇破坏了MSA神经元活动的节律性爆发模式。在MSA中观察到的变化不能归因于乙醇对从侧隔膜到MSA的传入事件的间接作用，因为乙醇没有改变侧隔膜细胞的神经活动。这些数据表明，乙醇并不是对所有神经元都有共同的作用。当血液中乙醇含量接近最大值时，MSA的神经活动从乙醇的急性作用中恢复，表明对乙醇的急性耐受。MSA神经活动变化的时间过程与行为镇静测量的时间过程高度相关，但与乙醇产生的体温过低无关。因此，本文的工作支持了乙醇对大鼠间隔区MSA神经元具有选择性作用的观点，这些作用可能影响乙醇诱导的行为镇静。
Evidence is provided in this manuscript that ethanol acts directly on neurons in the medial septal area (MSA). Initially, the electrophysiological characteristics of MSA neurons in freely moving rats were characterized and found similar to that observed in rats anesthetized with urethane, but not chloral hydrate. Therefore, urethane was used to evaluate the effects of ethanol in anesthetized rats. The conclusion that ethanol influences neural function in the MSA is based on electrophysiological data that ethanol (0.75-3.0 g/kg i.p.) suppresses neural firing of medial septal cells in urethane-anesthetized as well as in unanesthetized rats in a dose-related fashion. Concurrent with the suppression of firing rate, the rhythmic bursting pattern of activity of MSA neurons is disrupted by ethanol. The changes observed in the MSA could not be attributed to an indirect action of ethanol on afferents from the lateral septum to the MSA, because ethanol did not alter neural activity of cells in the lateral septum. These data indicate that ethanol does not have a common action on all neurons. Neural activity in the MSA recovered from the acute action of ethanol at a time when blood ethanol levels were near maximal, indicating an acute tolerance to this effect of ethanol. The time course of change in neural activity in the MSA was highly correlated with the time course of a measure of behavioral sedation, but not the hypothermia produced by ethanol. Thus, the work in this manuscript supports the view that ethanol has selective actions on MSA neurons in the rat septal area and that these actions may influence the behavioral sedation induced by ethanol.