Cost-effectiveness of hepatic resection versus percutaneous radiofrequency ablation for early hepatocellular carcinoma
Cost-effectiveness of hepatic resection versus percutaneous radiofrequency ablation for early hepatocellular carcinoma
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DOI：
10.1016/j.jhep.2013.04.009
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发表时间：
2013-08-01
影响因子：
25.7
通讯作者：
Pinna, Antonio D.
中科院分区：
文献类型：
--
作者：
Cucchetti, Alessandro;Piscaglia, Fabio;Pinna, Antonio D.
背景和目的：肝切除和射频消融（RFA）都被认为是肝细胞癌（HCC）的治疗方法，但其经济影响仍未确定。本研究的目的是分析早期HCC（米兰标准）的这两种策略的成本效益（CE）。方法：作为第一步，对过去十年相关文献进行了荟萃分析。 17项研究符合纳入标准：3996例患者已切除，4424例早期HCC进行了RFA。从荟萃分析获得的数据用于构建马尔可夫模型。从医疗保健提供者的角度评估了费用。蒙特卡洛概率敏感性分析用于估计每个治疗组的分布样本的分布样本。分辨率：从10年的角度来看，对于早期的HCC（单个结节）
Background & Aims: Both hepatic resection and radiofrequency ablation (RFA) are considered curative treatments for hepatocellular carcinoma (HCC), but their economic impact still remains not determined. Aim of the present study was to analyze the cost-effectiveness (CE) of these two strategies in early stage HCC (Milan criteria).Methods: As first step, a meta-analysis of the pertinent literature of the last decade was performed. Seventeen studies fulfilled the inclusion criteria: 3996 patients underwent resection and 4424 underwent RFA for early HCC. Data obtained from the meta-analysis were used to construct a Markov model. Costs were assessed from the health care provider perspective. A Monte Carlo probabilistic sensitivity analysis was used to estimate outcomes with distribution samples of 1000 patients for each treatment arm.Results: In a 10-year perspective, for very early HCC (single nodule