Spatial landscape of the tumor immune microenvironment.

Spatial landscape of the tumor immune microenvironment.
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肿瘤免疫微环境的空间景观。

DOI:
10.1016/j.trecan.2023.03.006
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发表时间:
2023
期刊:
影响因子:
18.4
通讯作者:
Han,Leng
Han,Leng
中科院分区:
医学1区
文献类型:
--
作者:
Chen,Yamei;Liu,Yuan;Han,Leng

文献摘要

相似文献

Karimi等人和Sorin等人最近在nature上发表的两项研究应用多路成像质细胞术(IMC)表征了脑肿瘤和肺腺癌(LUAD)中覆盖数百万细胞的单细胞肿瘤免疫景观。他们确定了与不同临床结果相关的特定细胞亚型和细胞-细胞相互作用,从而为肿瘤生物学和基于空间结构的预后预测提供了有价值的见解。
Two recent studies published inNatureby Karimi et al. and Sorin et al. applied multiplexed imaging mass cytometry (IMC) to characterize the single-cell tumor immune landscapes covering millions of cells in brain tumors and lung adenocarcinomas (LUAD). They identified specific cell subtypes and cell–cell interactions that correlate with distinct clinical outcomes, thus providing valuable insights into tumor biology and prognostic prediction based on spatial architecture.