Relationship between longitudinal changes in skeletal muscle characteristics over time and functional recovery during intensive rehabilitation of patients with subacute stroke
Relationship between longitudinal changes in skeletal muscle characteristics over time and functional recovery during intensive rehabilitation of patients with subacute stroke
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亚急性脑卒中患者强化康复过程中骨骼肌特征随时间的纵向变化与功能恢复的关系
DOI：
10.1080/10749357.2021.1940724
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发表时间：
2021
影响因子：
2.2
通讯作者：
Yamada Minoru
中科院分区：
文献类型：
--
作者：
Tanaka Shu;Ito Daisuke;Kimura Yosuke;Ishiyama Daisuke;Suzuki Mizue;Koyama Shingo;Narita Yuya;Masuda Hiroaki;Suzukawa Katsumi;Yamada Minoru
研究背景脑卒中是一种容易损害骨骼肌特性的疾病，导致骨骼肌数量少、质量低、力量差。然而，恢复过程中的中风患者的骨骼肌还没有很好地established.ObjectivesWe的目的是确定在强化康复过程中中风患者的骨骼肌特征的纵向变化，并检查其与功能recovery. MethodsEight-five中风患者的关系进行了前瞻性招募。我们将肌肉的数量和质量分别定义为超声检查的肌肉厚度和回声强度，并将肌肉力量定义为膝关节伸展力量。这些骨骼肌特征在四个时间点进行比较：入院时，2周后，4周后，出院时。我们还探讨了骨骼肌特性的变化与功能恢复之间的关系。（F = 5.838，P = .001），麻痹性股四头肌厚度（F = 2.943，P = 0.039），胫前肌厚度（F = 4.654，P = .004）随时间改善，麻痹侧股四头肌厚度的变化与平衡能力的恢复显著相关（比值比，1.05; 95%可信区间，1.00-1.09; P= .048）。结论本研究显示，膝关节伸展肌力量的非-麻痹侧和麻痹侧的股四头肌和胫骨前肌厚度随时间显著改善，麻痹侧股四头肌厚度的变化与恢复平衡能力。
BackgroundStroke is a disease that easily impairs skeletal muscle characteristics, resulting in low quantity, low quality, and poor strength. However, the recovery process of skeletal muscles in patients with stroke is not well established.ObjectivesWe aimed to determine the longitudinal changes in skeletal muscle characteristics in patients with stroke during intensive rehabilitation and examine their relationship with functional recovery.MethodsEighty-five patients with stroke were prospectively recruited. We defined muscle quantity and quality as ultrasonographic muscle thickness and echo intensity, respectively, and muscle strength as knee extension strength. These skeletal muscle characteristics were compared at four time points: on admission, after 2 weeks, after 4 weeks, and at discharge. We also explored the relationship between changes in skeletal muscle characteristics and functional recovery.ResultsNon-paretic knee extension torque (F = 5.838,P= .001), paretic quadriceps thickness (F = 2.943,P= .039), and paretic tibialis anterior thickness (F = 4.654,P= .004) improved over time, and changes in the paretic side quadriceps thickness were significantly associated with recovery for balance ability (odds ratio, 1.05; 95% confidence interval, 1.00–1.09;P= .048).ConclusionsThe present study revealed that knee extension muscle strength on the non-paretic side and quadriceps and tibialis anterior thickness on the paretic side significantly improved over time and that changes in the paretic side quadriceps thickness were associated with the recovery of balance ability.