β-adrenergic receptor responsiveness in aging heart and clinical implications.
β-adrenergic receptor responsiveness in aging heart and clinical implications.
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DOI：
10.3389/fphys.2013.00396
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发表时间：
2014-01-09
影响因子：
4
通讯作者：
Bonaduce D
中科院分区：
文献类型：
--
作者：
Ferrara N;Komici K;Corbi G;Pagano G;Furgi G;Rengo C;Femminella GD;Leosco D;Bonaduce D
老年健康个体运动耐量降低，左心室肌力储备减少，这与血管后负荷增加、动脉-心室负荷错配、身体失适应和自主调节受损（所谓的“β-肾上腺素能脱敏”）有关。肾上腺素能反应性随着年龄的增长而改变，年龄相关的变化仅限于β-肾上腺素能受体密度降低和β-肾上腺素受体- g蛋白-腺苷酸环化酶系统异常，而异常的类型和水平随物种和组织而变化。流行病学研究表明，老年心力衰竭的发病率和患病率较高，大量证据表明β-肾上腺素能系统的变化与心力衰竭的发病机制有关。特别是，众所周知：(a)儿茶酚胺水平与心力衰竭的死亡率和功能状态直接相关，(b) β1-肾上腺素能受体亚型在心力衰竭中下调，(c)心力衰竭依赖性心脏肾上腺素能反应性降低与G蛋白活性的变化有关。在这篇综述中，我们主要关注心血管β-肾上腺素能变化参与衰老过程，以及衰老心脏和心力衰竭之间的异同。
Elderly healthy individuals have a reduced exercise tolerance and a decreased left ventricle inotropic reserve related to increased vascular afterload, arterial-ventricular load mismatching, physical deconditioning and impaired autonomic regulation (the so called “β-adrenergic desensitization”). Adrenergic responsiveness is altered with aging and the age-related changes are limited to the β-adrenergic receptor density reduction and to the β-adrenoceptor-G-protein(s)-adenylyl cyclase system abnormalities, while the type and level of abnormalities change with species and tissues. Epidemiological studies have shown an high incidence and prevalence of heart failure in the elderly and a great body of evidence correlate the changes of β-adrenergic system with heart failure pathogenesis. In particular it is well known that: (a) levels of cathecolamines are directly correlated with mortality and functional status in heart failure, (b) β1-adrenergic receptor subtype is down-regulated in heart failure, (c) heart failure-dependent cardiac adrenergic responsiveness reduction is related to changes in G proteins activity. In this review we focus on the cardiovascular β-adrenergic changes involvement in the aging process and on similarities and differences between aging heart and heart failure.
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影响因子：
5.6
作者：
Corbi G;Bianco A;Turchiarelli V;Cellurale M;Fatica F;Daniele A;Mazzarella G;Ferrara N
通讯作者：
Ferrara N
影响因子：
3.7
作者：
Enns LC;Morton JF;Treuting PR;Emond MJ;Wolf NS;Dai DF;McKnight GS;Rabinovitch PS;Ladiges WC
通讯作者：
Ladiges WC
影响因子：
2.6
作者：
Corbi, Graziamaria;Acanfora, Domenico;Ferrara, Nicola
通讯作者：
Ferrara, Nicola
影响因子：
5
作者：
BOREA, PA;AMERINI, S;MUGELLI, A
通讯作者：
MUGELLI, A
影响因子：
7.2
作者：
Cannavo, Alessandro;Rengo, Giuseppe;Esposito, Giovanni
通讯作者：
Esposito, Giovanni