The role of germ cell loss during primordial follicle assembly: a review of current advances.
The role of germ cell loss during primordial follicle assembly: a review of current advances.
复制标题
原始卵泡组装过程中生殖细胞损失的作用：当前进展回顾
DOI：
10.7150/ijbs.18836
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发表时间：
2017
影响因子：
9.2
通讯作者：
Chen H
中科院分区：
文献类型：
--
作者：
Sun YC;Sun XF;Dyce PW;Shen W;Chen H
在大多数雌性哺乳动物中，早期生殖系发育始于原始生殖细胞（PGCs）的出现，并经过几个重要过程发育形成成熟的卵母细胞。生殖细胞凋亡和卵母细胞丢失发生在出生前后，这一点已被广泛接受。卵巢环境从胎儿到新生儿的转变与生殖细胞的损失和卵泡形成的时间相吻合。总而言之，在这一过渡时期，大约三分之二的生殖细胞会丢失。目前的共识是，生殖细胞损失可以归因于，至少部分归因于程序性细胞死亡（PCD）。最近，自噬被认为是分娩期间生殖细胞损失的一部分。本文就哺乳动物卵巢PCD在生殖细胞丧失过程中的主要观点和机制进行综述。我们还关注了自噬在生殖细胞丧失中的作用，并推测自噬可能也是原始卵泡池建立过程中的一个关键和必要的过程。
In most female mammals, early germline development begins with the appearance of primordial germ cells (PGCs), and develops to form mature oocytes following several vital processes. It remains well accepted that significant germ cell apoptosis and oocyte loss takes place around the time of birth. The transition of the ovarian environment from fetal to neonatal, coincides with the loss of germ cells and the timing of follicle formation. All told it is common to lose approximately two thirds of germ cells during this transition period. The current consensus is that germ cell loss can be attributed, at least in part, to programmed cell death (PCD). Recently, autophagy has been implicated as playing a part in germ cell loss during the time of parturition. In this review, we discuss the major opinions and mechanisms of mammalian ovarian PCD during the process of germ cell loss. We also pay close attention to the function of autophagy in germ cell loss, and speculate that autophagy may also serve as a critical and necessary process during the establishment of primordial follicle pool.