Cardiorespiratory fitness and accelerated cognitive decline with aging.
Cardiorespiratory fitness and accelerated cognitive decline with aging.
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随着年龄的增长，心肺健康和认知能力加速下降。
DOI：
10.1093/gerona/glt144
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Zonderman,AlanB
中科院分区：
文献类型：
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作者：
Wendell,CarringtonR;Gunstad,John;Waldstein,ShariR;Wright,JeanetteG;Ferrucci,Luigi;Zonderman,AlanB
越来越多的证据表明，自我报告的身体活动解释了老年人认知功能的变异性，有氧干预可能会改善这一人群的认知功能。然而，人们对心肺健康和认知功能在整个生命周期中的直接测量之间的纵向关联知之甚少。本研究探讨了前瞻性协会之间的限制性最大耗氧量（VO2max）和纵向性能上的综合neuropsychological battery.MethodsUp 1,400参与者年龄在19 - 94岁进行了初步VO2max评估，并完成了随后的测试记忆，注意力，知觉速度，语言和执行功能，除了认知筛查措施，最多6次（平均值，M = 2;标准差，SD = 1），最长18年（M = 7，SD = 3）。混合效应回归模型进行了调整人口，生物医学和行为confersider.ResultsAnalysisrevealed基线VO2max和轨迹的表现对多个措施的语言和视觉记忆，以及对认知筛选测试（allps <.05）之间的纵向关联。具有较低的VO2max的个人表现出加速的轨迹随着时间的推移，认知能力下降。ConclusionsBaseline心肺功能相关的纵向神经心理性能，记忆似乎是一个特别脆弱的域。有氧健身与认知能力加速下降有关的证据强调了行为干预对优化认知老化的重要性。
BackgroundGrowing evidence suggests that self-reported physical activity accounts for variability in cognitive function among older adults, and aerobic intervention may improve cognitive function in this population. However, much less is known about the longitudinal association between direct measures of cardiorespiratory fitness and cognitive function across the life span. The present study examined the prospective association between symptom-limited maximal oxygen consumption (VO2max) and longitudinal performance on a comprehensive neuropsychological battery.MethodsUp to 1,400 participants aged 19–94 years underwent initial VO2max assessment and completed subsequent tests of memory, attention, perceptuomotor speed, language, and executive function, in addition to cognitive screening measures, on up to six occasions (mean,M= 2; standard deviation,SD= 1) for up to 18 years (M= 7,SD= 3). Mixed-effects regression models were adjusted for demographic, biomedical, and behavioral confounders.ResultsAnalyses revealed significant longitudinal associations between baseline VO2max and trajectory of performance on multiple measures of verbal and visual memory, as well as on a cognitive screening test (allps < .05). Individuals with lower VO2max demonstrated accelerated trajectories of cognitive decline over time.ConclusionsBaseline cardiorespiratory fitness is related to longitudinal neuropsychological performance, and memory appears to be a particularly vulnerable domain. Evidence that aerobic fitness is associated with accelerated cognitive decline emphasizes the possible importance of behavioral interventions to optimize cognitive aging over time.