Heterogeneity of calbindin-containing neurons in the mouse main olfactory bulb: I. General description
Heterogeneity of calbindin-containing neurons in the mouse main olfactory bulb: I. General description
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DOI：
10.1016/j.neures.2010.04.009
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发表时间：
2010-08-01
影响因子：
2.9
通讯作者：
Kosaka, Katsuko
中科院分区：
文献类型：
--
作者：
Kosaka, Toshio;Kosaka, Katsuko
对小鼠主嗅球内钙结合蛋白阳性神经元的结构特征进行了研究。Calbindin阳性神经元分布不均匀，包括大量球周细胞、少量颗粒细胞、外丛状层中的中小型中间神经元以及位于外丛状层、内丛状层、颗粒细胞层和室管膜/室管膜下层的大型短轴突细胞。这些大的短轴突细胞也是异质的;一些对应于经典鉴定的短轴突细胞，如Blanes细胞、高尔基体细胞、水平细胞和垂直细胞，但另一些似乎是以前未鉴定的。也遇到了一些微弱的钙结合蛋白阳性假定簇状细胞。在MOB室管膜/室管膜下层附近，一些钙结合蛋白阳性的短轴突细胞或多或少地平行于矢状面延伸其树突状突起，推测对应于最近命名的髓细胞。此外，我们还在内网状层中发现了一些Calbindin阳性的水平细胞，它们的轴突向外侧嗅束延伸，其中一个细胞的轴突已被证实延伸到外侧嗅束，这表明它们可能是投射神经元之一。本研究揭示了小鼠MOB中钙结合蛋白阳性神经元的多样性及其迄今未知的特殊结构特性。(C)2010年爱思唯尔爱尔兰有限公司和日本神经科学学会。All rights reserved.
The structural features of calbindin-positive neurons were studied in the mouse main olfactory bulb (MOB). Calbindin-positive neurons were heterogeneous, including numerous periglomerular cells, a few granule cells, small to medium-sized interneurons in the external plexiform layer, and large short-axon cells located in the external plexiform layer, internal plexiform layer, granule cell layer and ependymal/subependymal layer. These large short-axon cells were also heterogeneous; some corresponded to classically identified short-axon cells such as Blanes cells, Golgi cells, horizontal cells and vertical cells, but some others appeared to be previously unidentified. A few faintly calbindin-positive presumed tufted cells were also encountered. Near the ependymal/subependymal layer of the MOB some calbindin-positive short-axon cells extended their dendritic processes more or less parallel to the sagittal plane, presumably corresponding to medullary cells named recently. In addition we encountered a few calbindin-positive horizontal cells in the internal plexiform layer extending their axons toward the lateral olfactory tract, one of which was confirmed to extend its axon into the lateral olfactory tract, indicating that they were presumed to be one of projection neurons. The present study revealed the diversity of calbindin-positive neurons in the mouse MOB and their particular structural properties hitherto unknown. (C) 2010 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.