Autophagy is an important metabolic pathway to determine leukemia cell survival following suppression of the glycolytic pathway
Autophagy is an important metabolic pathway to determine leukemia cell survival following suppression of the glycolytic pathway
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DOI：
10.1016/j.bbrc.2016.04.098
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发表时间：
2016-05-20
影响因子：
3.1
通讯作者：
Ito, Kousei
中科院分区：
文献类型：
--
作者：
Kawaguchi, Moemi;Aoki, Shigeki;Ito, Kousei
大多数癌细胞主要通过糖酵解产生能量，即使在有足够氧气的情况下也是如此。因此，抑制糖酵解是一个有前途的癌症治疗靶点。最近，人们认识到，要进行彻底的癌症治疗，全面了解癌症代谢是必不可少的，而不仅仅是关注糖酵解。在这里，我们研究了自噬的支持机制，这是一个分解代谢过程，使细胞内成分，在糖酵解抑制条件下的能量供应。自噬被认为在癌症中高度活化，并通过适应周围恶劣的微环境来促进其生长或进展。我们发现，癌细胞积极促进自噬，以克服糖酵解的能量短缺，通过维持生存所必需的ATP生产的线粒体活性。总之，自噬在决定癌细胞的生存或死亡中起作用，并且癌细胞中的自噬能力是有希望的治疗靶点。(C)2016 Elsevier Inc. All rights reserved.
Most cancer cells predominantly produce energy by glycolysis, even in the presence of adequate oxygen. Therefore, inhibition of glycolysis is a promising cancer treatment target. Recently, it has been recognized that to conduct thorough treatment of cancer, comprehensive understanding of cancer metabolism is essential, not only focusing on glycolysis. Here, we investigated the supporting mechanism of autophagy, which is a catabolic process that recycles intracellular components, for energy supply in the glycolysis-inhibited condition. Autophagy is thought to be highly activated in cancers and to promote their growth or progression by adapting to the harsh surrounding microenvironment. We found that cancer cells positively promoted autophagy to overcome the energy shortage from glycolysis by maintaining mitochondrial activity for ATP production essential for survival. Conclusively, autophagy plays a role in determining whether cancer cells live or die, and autophagic ability in cancer cells is a promising target for therapy. (C) 2016 Elsevier Inc. All rights reserved.